Interferon production in glia and glioma cell lines

Research output: Contribution to journalArticle

Abstract

Interferon (IF) was produced in glia and glioma cell lines in titers comparable to those produced by human fibroblasts. It was inducible by both Sendai virus and polyriboinosinic:polyribocytidylic acid. "Superinduction" resulted in up to 500-fold-higher titers of IF. The IF appeared to be of the fibroblast type, as revealed by experiments using heat treatment, assay of antiviral activity in heterologous cell lines, and neutralization with specific antisera. Since large amounts of IF may easily be produced with glioma cell lines, such cells may be suitable for mass production of IF.

Details

Authors
  • Inger Larsson
  • Lars-Erik Landström
  • Ebba Larner
  • Erik Lundgren
  • Håkan Miörner
  • Örjan Strannegård
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
Original languageEnglish
Pages (from-to)786-789
JournalInfection and Immunity
Volume22
Issue number3
Publication statusPublished - 1978
Publication categoryResearch
Peer-reviewedYes