Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria

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Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria. / Benson, Mikael; Jodal, Ulf; Agace, William; Hellström, Mikael; Mårild, Staffan; Rosberg, Sten; Sjöström, Michael; Wettergren, Björn; Jönsson, Susanne; Svanborg, Catharina.

In: Journal of Infectious Diseases, Vol. 174, No. 5, 01.01.1996, p. 1080-1084.

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Harvard

Benson, M, Jodal, U, Agace, W, Hellström, M, Mårild, S, Rosberg, S, Sjöström, M, Wettergren, B, Jönsson, S & Svanborg, C 1996, 'Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria', Journal of Infectious Diseases, vol. 174, no. 5, pp. 1080-1084. https://doi.org/10.1093/infdis/174.5.1080

APA

Benson, M., Jodal, U., Agace, W., Hellström, M., Mårild, S., Rosberg, S., Sjöström, M., Wettergren, B., Jönsson, S., & Svanborg, C. (1996). Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria. Journal of Infectious Diseases, 174(5), 1080-1084. https://doi.org/10.1093/infdis/174.5.1080

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MLA

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Author

Benson, Mikael ; Jodal, Ulf ; Agace, William ; Hellström, Mikael ; Mårild, Staffan ; Rosberg, Sten ; Sjöström, Michael ; Wettergren, Björn ; Jönsson, Susanne ; Svanborg, Catharina. / Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria. In: Journal of Infectious Diseases. 1996 ; Vol. 174, No. 5. pp. 1080-1084.

RIS

TY - JOUR

T1 - Interleukin (IL)-6 and IL-8 in children with febrile urinary tract infection and asymptomatic bacteriuria

AU - Benson, Mikael

AU - Jodal, Ulf

AU - Agace, William

AU - Hellström, Mikael

AU - Mårild, Staffan

AU - Rosberg, Sten

AU - Sjöström, Michael

AU - Wettergren, Björn

AU - Jönsson, Susanne

AU - Svanborg, Catharina

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.

AB - Urine and serum interleukin (IL)-6 and IL-8 responses were higher in children with febrile urinary tract infection (n = 61) than in those with asymptomatic bacteriuria (n = 39). By univariate analysis, cytokine levels were related to age, sex, reflux, renal scarring, urine leukocytes, C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), and bacterial properties (P fimbriae but not hemolysin). Multivariate modeling showed that urine IL-6 responds were higher in girls than boys, increased with age, and were positively associated with CRP, ESR, serum IL-6, and urine leukocyte counts. The urine IL-8 response was not influenced by age, but it was influenced by P fimbriae and was associated with ESR, CRP, urine leukocytes, and female sex. The results show that cytokine responses to urinary tract infection vary with the severity of infection and that cytokine activation is influenced by a variety of host and bacterial variables.

U2 - 10.1093/infdis/174.5.1080

DO - 10.1093/infdis/174.5.1080

M3 - Article

C2 - 8896512

AN - SCOPUS:19244363702

VL - 174

SP - 1080

EP - 1084

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 1537-6613

IS - 5

ER -