Interleukin-1 potentiates glucose stimulated insulin release in the isolated perfused pancreas

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The acute effects of recombinant human interleukin-1 beta (rIL-1) on basal and glucose-stimulated insulin release were investigated in the isolated perfused pancreas. At a concentration of 20 μg/l rIL-1 had no effect on basal insulin release, but increased the total amount of insulin released during first and second phase insulin release in response to 20 mmol/l D-glucose in the rat pancreas (P < 0.05). In addition, 26 μg/l of rIL-1 potentiated insulin release in response to square wave infusions of stimulatory concentrations of glucose (11 mmol/l) in the porcine pancreas. We hypothesize that IL-1 in the systemic circulation may affect B cell function in vivo.


External organisations
  • Steno Diabetes Center Copenhagen
Original languageEnglish
Pages (from-to)302-306
Number of pages5
JournalActa Endocrinologica
Issue number3
Publication statusPublished - 1988 Jan 1
Publication categoryResearch
Externally publishedYes