Interleukin-1β regulation of islet and thyroid autoimmunity in the BB rat

Research output: Contribution to journalArticle


Daily injections of high dose human recombinant interleukin-1β (IL-1β) accelerated the onset of both insulin-dependent diabetes mellitus and lymphocytic thyroiditis in genetically prone BB rats. In diabetes-resistant BB rats, high dose IL-1β failed to induce diabetes. Additionally, the presence of neutralizing IL-1β antibodies in these rats strongly correlated with inhibition of lymphocytic thyroiditis. Since low dose IL-1β protects diabetes-prone rats from IDDM, we conclude that IL-1β is a potent modulator of autoimmune diabetes and thyroid disease in genetically susceptible rats.


  • Sarah Vertrees
  • Cindy A. Wilson
  • Roel Ubungen
  • Deborah Wilson
  • Denis G. Baskin
  • Bert Toivola
  • Cindy Jacobs
  • Norman Boiani
  • Paul Baker
  • Åke Lernmark
External organisations
  • University of Washington, Seattle
Original languageEnglish
Pages (from-to)717-732
Number of pages16
JournalJournal of Autoimmunity
Issue number5
Publication statusPublished - 1991 Jan 1
Publication categoryResearch
Externally publishedYes