International multi-institutional bench mark study on dosimetric and volumetric modulation using helical tomotherapy treatment planning for malignant pleural mesothelioma tumors

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding


Determining the most desirable and achievable target dose and organ at risk (OAR) sparing using helical TomoTherapy planning system for mesothelioma treatment plans. A range of planning parameters was used. The reviewers’ ranking assessment (Ranking in Groups: 1 = Good, 2 = Above Average, 3 = Average, 4 = Poor).The overall rankings revealed that a plan with a balanced tradeoff among all planning objectives was preferred by most participants and reviewers. Other studies found low doses to the contralateral lung to be limiting. This was not the case in our study, with TomoTherapy we found the dose to contra lateral lung to be as low as V5Gy=0.87%. A pitch value of 0.287 or 0.43 would provide better result. A delivered modulation factor of above 1.7 and a treatment time around 500 sec will be beneficial consideration in planning.


  • Allen Movahed
  • Tommy Knöös
  • Claire Foottit
  • André Haraldsson
  • Dirk Verellen
  • Koen Tournel
  • Sharon Qi
  • Dale Matson
  • Thuy Lau
  • Milton Vargas
  • Somsak Wanwilairat
  • Christine Higby
  • Osama Hassad
  • Belal Moftah
  • Thomas Lacornerie
  • Antoine Wagner
  • Hew Choon Soong
External organisations
  • The Ottawa Hospital
  • University of California, Los Angeles
  • King Faisal Specialist Hospital and Research Centre
  • Centre Oscar Lambret
  • Skåne University Hospital
  • Pomona Valley Hospital Medical Center, Pomona, CA
  • Universitair Ziekenhuis Brussel
  • Gamma West Cancer Services, Utah
  • Cancer Center Chihuahua, Hospital Angeles Chihuahua
  • Maharaj Nakorn Chiang Mai Hospital, Chiang Mai
  • Subang Jaya Medical Centre, Selangor
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging


  • Dosimetric, Mesothelioma, TomoTherapy planning, Volumetric
Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering, 2015
EditorsDavid A. Jaffray
Place of PublicationCham
PublisherSpringer Verlag
Number of pages3
ISBN (Electronic)9783319193878
ISBN (Print)978-3-319-19386-1
Publication statusPublished - 2015 Jan 1
Publication categoryResearch
EventWorld Congress on Medical Physics and Biomedical Engineering, 2015 - Toronto, Canada
Duration: 2015 Jun 72015 Jun 12

Publication series

NameIFMBE Proceedings


ConferenceWorld Congress on Medical Physics and Biomedical Engineering, 2015