Interstitial laser-induced thermotherapy: Influence of carbonization on lesion size

Research output: Contribution to journalArticle


Background and Objective: The size of laser-induced coagulated lesions produced in porcine muscle in vitro using a cylindrical diffusing fiber tip and a conductive heat source, made by covering the diffuser with a hollow steel needle, were compared to investigate the influence of charring. Materials and methods: Light from a Nd: YAG laser was utilized for thermotherapy. A theoretical model for calculating tissue temperature was used to predict the experimental results and to simulate in vivo treatments. Results: The metal-covered tip produced carbonization and tissue vaporization that was not found with the diffuser. After 20 min of irradiation at a laser power of 7 W, the coagulated volumes with and without carbonization were found to be 13.1 cm(3) (range 12.4-14.1 cm(3), n = 4) and 12.2 cm(3) (range 11.5-13.4 cm(3), n = 4), respectively. Mathematical simulations showed that in unperfused tissue, a diffusing laser heat source produces smaller lesions than does a conductive heat source at the same power, the difference in coagulated volume becoming smaller with increased treatment time and increased power. Conclusion: Using cylindrical diffusers, interstitial laser-induced thermotherapy without carbonization at the fiber tip can be as efficient as treatment with carbonization. (C) 1998 Wiley-Liss, Inc.


  • C Sturesson
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Atom and Molecular Physics and Optics
Original languageEnglish
Pages (from-to)51-57
JournalLasers in Surgery and Medicine
Issue number1
Publication statusPublished - 1998
Publication categoryResearch
Externally publishedYes