Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson's Disease.

Research output: Contribution to journalArticle


Nonmotor symptoms (NMS) fluctuate in conjunction with motor oscillations in advanced Parkinson's disease (PD), though little is known about the variability of NMS fluctuations in individual patients. We aimed to assess within-patient variability in frequency and severity of NMS during a series of five patient-perceived motor On and Off periods in 38 fluctuating PD patients from the multicenter NonMotorFluctuations in PD study using a visual analogue scale. NMS frequency and severity appeared moderately variable in both motor states within individual patients. Symptom severity ranges between motor states showed high variability and were larger in motor Off states for most NMS.


  • Mareike Fauser
  • Matthias Löhle
  • Georg Ebersbach
  • Per Odin
  • Gerd Fuchs
  • Wolfgang H Jost
  • K Ray Chaudhuri
  • Rainer Koch
  • Alexander Storch
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)737-741
JournalJournal of Parkinson's Disease
Issue number4
Publication statusPublished - 2015
Publication categoryResearch