Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.
Research output: Contribution to journal › Article
The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Journal of Neuroimmunology|
|Publication status||Published - 2010|
Related research output
2010, Avd för neurokirurgi/Lunds Stamcellscentrum, Inst för kliniska vetenskaper, Lunds Universitet. 104 p.
Research output: Thesis › Doctoral Thesis (compilation)