Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.

Research output: Contribution to journalArticle

Abstract

The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.

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Subject classification (UKÄ) – MANDATORY

  • Neurology
Original languageEnglish
Pages (from-to)140-144
JournalJournal of Neuroimmunology
Volume218
Issue number1-2
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes

Related research output

Gunnarsson, S., 2010, Avd för neurokirurgi/Lunds Stamcellscentrum, Inst för kliniska vetenskaper, Lunds Universitet. 104 p.

Research output: ThesisDoctoral Thesis (compilation)

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