Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.

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Bibtex

@article{0f6f9126bf154a918859a335f75ec95a,
title = "Intra-tumour IgA1 is common in cancer and is correlated with poor prognosis in bladder cancer.",
abstract = "A high frequency of IgA1-positive tumour cells was found in tissue micro-arrays of oesophagus, colon, testis, lung, breast, bladder and ovarian cancer. IgA1 was observed in the cytoplasm and the plasma membrane. A correlation was found between intra-tumour IgA1 and poor overall survival in a large cohort of bladder cancer patients (n = 99, p = 0.011, log-rank test). The number of IgA1-positive tumour cells was also found to be higher in female than male bladder cancer patients. The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis. Uptake of IgA1 was also observed in breast cancer and melanoma cell lines when cultivated in the presence of serum from healthy individuals, indicating a possible origin of the IgA1 antibodies in cancer cells.",
keywords = "Medicine",
author = "Charlotte Welinder and Karin Jirstr{\"o}m and Sophie Lehn and Bj{\"o}rn Nodin and Gy{\"o}rgy Marko-Varga and Ola Blixt and Lena Danielsson and Bo Jansson",
year = "2016",
doi = "10.1016/j.heliyon.2016.e00143",
language = "English",
volume = "2",
journal = "Heliyon",
issn = "2405-8440",
publisher = "Elsevier",
number = "8",

}