Involvement of the CD1d-Natural killer T cell pathway in neointima formation after vascular injury

Research output: Contribution to journalArticle

Abstract

Recent studies have established that the immune system plays an important role in the development of atherosclerosis. However, its role in regulating the arterial response to mechanical injury is less well studied. Arterial injury is associated with local accumulation of antibodies, and mice lacking functional T and B cells exhibit increased neointima formation, indicating that adaptive immune responses to neoantigens in the damaged tissue modulate the vascular repair process. To study the role of lipid antigen presentation in the arterial response to injury, we analyzed neointima formation in mice deficient in the lipid antigen-presenting molecule CD1d using a carotid collar model. As compared with control mice, neointima formation was reduced by >60% (P<0.01) in CD1d(-/-) mice. Moreover, carotid injury of wild-type C57BL/6 mice was associated with expansion of CD1d-restricted natural killer T cells in the spleen and accumulation of natural killer T cells in the periadventitial space of injured arteries. The results suggest that presentation of lipid antigens through the CD1d-natural killer T cell pathway modulates vascular repair responses.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • arterial injury, antigen presentation, neointima
Original languageEnglish
Pages (from-to)E83-E89
JournalCirculation Research
Volume101
Issue number8
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

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Maria Wigren, 2011, Experimental Cardiovascular Research Unit, Lund University. 130 p.

Research output: ThesisDoctoral Thesis (compilation)

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