Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents

Research output: Contribution to journalArticle

Abstract

A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO2Me) gave excellent yields (89%).

Details

Authors
External organisations
  • ACADIA Pharmaceuticals AB
Original languageEnglish
Pages (from-to)1771-1773
Number of pages3
JournalOrganic Letters
Volume8
Issue number9
Publication statusPublished - 2006 Apr 27
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes