Is intracranial volume a suitable proxy for brain reserve? Rik Ossenkoppele

Research output: Contribution to journalReview article

Abstract

Background: Brain reserve is a concept introduced to explain why Alzheimer's disease (AD) patients with a greater brain volume prior to onset of pathology generally have better clinical outcomes. In this review, we provide a historical background of the emergence of brain reserve and discuss several aspects that need further clarification, including the dynamic or static nature of the concept and its underlying mechanisms and clinical effect. We then describe how brain reserve has been operationalized over the years, and critically evaluate the use of intracranial volume (ICV) as the most widely used proxy for brain reserve. Furthermore, we perform a meta-analysis showing that ICV is associated with higher cognitive performance after adjusting for the presence and amount of pathology. Although we acknowledge its imperfections, we conclude that the use of ICV as a proxy for brain reserve is currently warranted. However, further development of more optimal measures of brain reserve as well as a more clearly defined theoretical framework is essential.

Details

Authors
  • Anna Catharina Van Loenhoud
  • Colin Groot
  • Jacob William Vogel
  • Wiesje Maria Van Der Flier
  • Rik Ossenkoppele
Organisations
External organisations
  • VU University Medical Center
  • McGill University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Alzheimer's disease, Brain reserve, Dementia, Intracranial volume, MRI, Resilience
Original languageEnglish
Article number91
JournalAlzheimer's Research and Therapy
Volume10
Issue number1
Publication statusPublished - 2018 Sep 11
Publication categoryResearch
Peer-reviewedYes