Ischemic stroke rates decline in patients with atrial fibrillation as anticoagulants uptake improves: A Swedish cohort study

Research output: Contribution to journalArticle


Introduction The impact of the increased anticoagulants uptake on incidence rate of ischemic stroke is largely unknown. We assessed time trends in rates of ischemic stroke in patients with incident atrial fibrillation (AF) diagnosed between 2011 and 2013. Materials and methods Population-based retrospective registry study of all 11,500 adults diagnosed with incident non-valvular atrial fibrillation in 2011–2013 in primary and secondary care and receiving oral anticoagulants (n = 4847), aspirin (n = 2850) or no treatment (n = 3766) in Skåne County, Sweden. The primary outcome was the rate of ischemic stroke within 365 days after AF diagnosis. Results and conclusion Cumulative incidence of ischemic stroke decreased from 2.87% (95% confidence interval (CI) 2.37–3.45%) to 1.93% (95% CI 1.54–2.41%) while the uptake of oral anticoagulants increased from 36.6% to 48.4% between 2011 and 2013 (regression coefficient − 0.08; 95% CI, − 0.09 to − 0.07, p < 0.001). The increased uptake of oral anticoagulants in the community is associated with decreased incidence of ischemic stroke in AF patients.


External organisations
  • Skåne University Hospital
  • Umeå University
  • Department of Medicines Management and Informatics in Skåne County
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems


  • Anticoagulants, Atrial fibrillation, Cohort studies, Incidence, Stroke
Original languageEnglish
Pages (from-to)44-48
Number of pages5
JournalThrombosis Research
Publication statusPublished - 2017 Oct 1
Publication categoryResearch

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