Islet cell antibody reactivity with human fetal pancreatic islets

Research output: Contribution to journalArticle

Abstract

To evaluate the possibility of autoimmune processes against pancreatic islets in fetal life, we tested islet cell antibody (ICA) reactivity with 14 fetal pancreata obtained after abortion at the 15th up to the 19th week of gestation. Pancreatic islets positive for a monoclonal proinsulin antibody but non-reactive with ICA negative control serum were found in 9 14 pancreata and all ( 9 9) of them showed a positive reaction with the ICA standard. It is concluded that ICA reactivity may be detected in fetal human pancreata. Further studies on fetal islet cell antibody reactivity in the development of insulin dependent diabetes mellitus (IDDM) are warranted.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Lund University
  • University of Washington, Seattle
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes

Keywords

  • Autoimmunity, Fetal islets, Islet cell antibodies, Islet cell antigens
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume14
Issue number1
Publication statusPublished - 1991 Jan 1
Publication categoryResearch
Peer-reviewedYes