Islet Cell Cytoplasmic Antibodies (ICA) in Diabetes and Disorders of Glucose Tolerance

Research output: Contribution to journalArticle


Islet cell cytoplasmic antibodies were determined in 85 individuals 60 to 74 years old with fasting hyperglycaemia, in 65 patients with cystic fibrosis, in 113 patients with pancreatitis, in 21 patients with Turner's phenotype, and in 135 first‐degree relatives of patients with Type 1 (insulin‐dependent) diabetes. Islet cell antibodies were absent in all 60 to 74‐year‐old subjects with fasting hyperglycaemia detected by screening, and who did not require insulin treatment within 3 years. Islet cell antibodies were also absent in all patients with pancreatitis, cystic fibrosis, or Turner's phenotype. Islet cell antibodies were detected in 2 out of 135 (1.5 %) first‐degree relatives of new Type 1 diabetic patients, and in 1 out of 371 (0.3%) non‐diabetic control subjects. During 12 years of follow‐up 1 of the 2 first‐degree relatives with islet cell antibodies and the only positive control developed Type 1 diabetes. It is suggested that islet cell antibodies are primarily associated with Type 1 diabetes and not with other disorders of glucose tolerance. 1991 Diabetes UK


  • B. Marner
  • G. Bille
  • M. Christy
  • E. M. Damsgaard
  • S. Garne
  • E. Heinze
  • S. Larsen
  • Å Lernmark
  • T. Mandrup‐Poulsen
  • J. Nerup
  • M. Schroll
External organisations
  • Hagedorn Research Institute
  • Frederiksberg Hospital
  • Odense University Hospital
  • Copenhagen University Hospital
  • University of Ulm
  • Glostrup Hospital
  • University of Washington
  • Steno Diabetes Center Copenhagen
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes


  • Cystic fibrosis, Diabetes mellitus, Family history, Islet cell antibodies, Pancreatitis, Relatives, Turner's syndrome
Original languageEnglish
Pages (from-to)812-816
JournalDiabetic Medicine
Issue number9
Publication statusPublished - 1991 Jan 1
Publication categoryResearch
Externally publishedYes