Islet Transplantation in Mice Differing in the I and S Subregions of the H‐2 Complex: Effects of Presensitization with Skin Allografts

Research output: Contribution to journalArticle

Abstract

Pancreatic islets from A.TH mice were transplanted into the spleen or streptozotocin (SZ)‐diabetic A.TL mice. The two strains of mice are congenic inbred strains, differing only in the I and S subregions of the H‐2 complex. The allogeneic islet grafts decreased blood glucose temporarily, but the islets were rejected after 21 ± 7 days (mean ± SD). The effect of skin presensitization was tested by giving both allogeneic and syngeneic skin grafts to each of a second set of A.TL mice before streptozotocin treatment and islet transplantation. The time course of rejection of the allogeneic islets in animals that received initial skin grafts was decreased to 8 ± 3 days. In both skin‐presensitized and non‐presensitized mice syngeneic islet grafts were able to restore normoglycaemia, even in animals that had previously rejected an islet allograft. These observations demonstrate that transplantation of pancreatic islet allografts across the I and S subregions of the H‐2 complex is sufficient to induce rejection of the islets. The islet rejection was markedly accelerated by prior sensitization with allogeneic skin grafting. It is suggested that elements in allogeneic skin grafts serve as inducers of cytotoxic T‐cell responses directed against gene products of the I and/or S subregions present on cells in the allogeneic islets.

Details

Authors
External organisations
  • Hagedorn Research Institute
Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalScandinavian Journal of Immunology
Volume16
Issue number1
Publication statusPublished - 1982 Jan 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes