Isolation of rat major histocompatibility genes expressed in pancreatic β-cells

Research output: Contribution to journalArticle


The probable role of cell surface antigens in the development of juvenile diabetes necessitates a detailed study of the proteins expressed on the surface of pancreatic β-cells. A gene library composed of genes expressed in β-cells was constructed to provide a source of low abundance genes from those cells. Initial studies with this library have led to the isolation of three genes which share nucleotide and amino acid sequence homology with mouse and human class I major histocompatibility antigens.


External organisations
  • Hagedorn Research Institute
Original languageEnglish
Pages (from-to)1135-1138
Number of pages4
JournalActa Biologica et Medica Germanica
Issue number12
Publication statusPublished - 1983 Jan 1
Publication categoryResearch
Externally publishedYes