K-ATP-channels and glucagon secretion glucose-regulated

Research output: Contribution to journalReview article

Abstract

Glucagon, secreted by the a-cells of the pancreatic islets, is the most important glucose-increasing hormone of the body. The precise regulation of glucagon release remains incompletely defined but has been proposed to involve release of inhibitory factors from neighbouring P-cells (paracrine control). However, the observation that glucose can regulate glucagon secretion under conditions when insulin secretion does not occur argues that the a-cell is also equipped with its own intrinsic (exerted within the a-cell itself) glucose sensing. Here we consider the possible mechanisms involved with a focus on ATP-regulated K+-channels and changes in a-cell membrane potential.

Details

Authors
  • Patrik Rorsman
  • S Albert Salehi
  • Fernando Abdulkader
  • Matthias Braun
  • Patrick E. MacDonald
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes
Original languageEnglish
Pages (from-to)277-284
JournalTrends in Endocrinology and Metabolism
Volume19
Issue number8
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes