Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

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Bibtex

@article{7553dae4046442ca8c4578d32d2b97af,
title = "Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease",
abstract = "We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6{\%} to 17{\%} increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.",
author = "Heribert Schunkert and Koenig, {Inke R.} and Sekar Kathiresan and Reilly, {Muredach P.} and Assimes, {Themistocles L.} and Hilma Holm and Michael Preuss and Stewart, {Alexandre F. R.} and Maja Barbalic and Christian Gieger and Devin Absher and Zouhair Aherrahrou and Hooman Allayee and David Altshuler and Anand, {Sonia S.} and Karl Andersen and Anderson, {Jeffrey L.} and Diego Ardissino and Ball, {Stephen G.} and Balmforth, {Anthony J.} and Barnes, {Timothy A.} and Becker, {Diane M.} and Becker, {Lewis C.} and Klaus Berger and Bis, {Joshua C.} and Boekholdt, {S. Matthijs} and Eric Boerwinkle and Braund, {Peter S.} and Brown, {Morris J.} and Burnett, {Mary Susan} and Ian Buysschaert and Carlquist, {John F.} and Li Chen and Sven Cichon and Veryan Codd and Davies, {Robert W.} and George Dedoussis and Abbas Dehghan and Serkalem Demissie and Devaney, {Joseph M.} and Patrick Diemert and Ron Do and Angela Doering and Sandra Eifert and {El Mokhtari}, {Nour Eddine} and Ellis, {Stephen G.} and Roberto Elosua and Engert, {James C.} and Epstein, {Stephen E.} and {de Faire}, Ulf and Marcus Fischer and Folsom, {Aaron R.} and Jennifer Freyer and Bruna Gigante and Domenico Girelli and Solveig Gretarsdottir and Vilmundur Gudnason and Gulcher, {Jeffrey R.} and Eran Halperin and Naomi Hammond and Hazen, {Stanley L.} and Albert Hofman and Horne, {Benjamin D.} and Thomas Illig and Carlos Iribarren and Jones, {Gregory T.} and Jukema, {J. Wouter} and Kaiser, {Michael A.} and Kaplan, {Lee M.} and Kastelein, {John J. P.} and Kay-Tee Khaw and Knowles, {Joshua W.} and Genovefa Kolovou and Augustine Kong and Reijo Laaksonen and Diether Lambrechts and Karin Leander and Guillaume Lettre and Mingyao Li and Wolfgang Lieb and Christina Loley and Lotery, {Andrew J.} and Mannucci, {Pier M.} and Seraya Maouche and Nicola Martinelli and McKeown, {Pascal P.} and Christa Meisinger and Thomas Meitinger and Olle Melander and Merlini, {Pier Angelica} and Vincent Mooser and Thomas Morgan and Muehleisen, {Thomas W.} and Muhlestein, {Joseph B.} and Thomas Muenzel and Kiran Musunuru and Janja nahrstaedt and Nelson, {Christopher P.} and Noethen, {Markus M.} and Oliviero Olivieri and Patel, {Riyaz S.} and Patterson, {Chris C.} and Annette Peters and Flora Peyvandi and Liming Qu and Quyyumi, {Arshed A.} and Rader, {Daniel J.} and Rallidis, {Loukianos S.} and Catherine Rice and Rosendaal, {Frits R.} and Diana Rubin and Veikko Salomaa and Sampietro, {M. Lourdes} and Sandhu, {Manj S.} and Eric Schadt and Arne Schaefer and Arne Schillert and Stefan Schreiber and Juergen Schrezenmeir and Schwartz, {Stephen M.} and Siscovick, {David S.} and Mohan Sivananthan and Suthesh Sivapalaratnam and Albert Smith and Smith, {Tamara B.} and Snoep, {Jaapjan D.} and Nicole Soranzo and Spertus, {John A.} and Klaus Stark and Kathy Stirrups and Monika Stoll and Tang, {W. H. Wilson} and Stephanie Tennstedt and Gudmundur Thorgeirsson and Gudmar Thorleifsson and Maciej Tomaszewski and Uitterlinden, {Andre G.} and {van Rij}, {Andre M.} and Voight, {Benjamin F.} and Wareham, {Nick J.} and Wells, {George A.} and H-Erich Wichmann and Wild, {Philipp S.} and Christina Willenborg and Witteman, {Jaqueline C. M.} and Wright, {Benjamin J.} and Shu Ye and Tanja Zeller and Andreas Ziegler and Francois Cambien and Goodall, {Alison H.} and Cupples, {L. Adrienne} and Thomas Quertermous and Winfried Maerz and Christian Hengstenberg and Stefan Blankenberg and Ouwehand, {Willem H.} and Hall, {Alistair S.} and Panos Deloukas and Thompson, {John R.} and Kari Stefansson and Robert Roberts and Unnur Thorsteinsdottir and O'Donnell, {Christopher J.} and Ruth McPherson and Jeanette Erdmann and Samani, {Nilesh J.}",
year = "2011",
doi = "10.1038/ng.784",
language = "English",
volume = "43",
pages = "333--U153",
journal = "Nature Genetics",
issn = "1546-1718",
publisher = "Nature Publishing Group",
number = "4",

}