Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

Research output: Contribution to journalArticle

Standard

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. / Schunkert, Heribert; Koenig, Inke R.; Kathiresan, Sekar; Reilly, Muredach P.; Assimes, Themistocles L.; Holm, Hilma; Preuss, Michael; Stewart, Alexandre F. R.; Barbalic, Maja; Gieger, Christian; Absher, Devin; Aherrahrou, Zouhair; Allayee, Hooman; Altshuler, David; Anand, Sonia S.; Andersen, Karl; Anderson, Jeffrey L.; Ardissino, Diego; Ball, Stephen G.; Balmforth, Anthony J.; Barnes, Timothy A.; Becker, Diane M.; Becker, Lewis C.; Berger, Klaus; Bis, Joshua C.; Boekholdt, S. Matthijs; Boerwinkle, Eric; Braund, Peter S.; Brown, Morris J.; Burnett, Mary Susan; Buysschaert, Ian; Carlquist, John F.; Chen, Li; Cichon, Sven; Codd, Veryan; Davies, Robert W.; Dedoussis, George; Dehghan, Abbas; Demissie, Serkalem; Devaney, Joseph M.; Diemert, Patrick; Do, Ron; Doering, Angela; Eifert, Sandra; El Mokhtari, Nour Eddine; Ellis, Stephen G.; Elosua, Roberto; Engert, James C.; Epstein, Stephen E.; de Faire, Ulf; Fischer, Marcus; Folsom, Aaron R.; Freyer, Jennifer; Gigante, Bruna; Girelli, Domenico; Gretarsdottir, Solveig; Gudnason, Vilmundur; Gulcher, Jeffrey R.; Halperin, Eran; Hammond, Naomi; Hazen, Stanley L.; Hofman, Albert; Horne, Benjamin D.; Illig, Thomas; Iribarren, Carlos; Jones, Gregory T.; Jukema, J. Wouter; Kaiser, Michael A.; Kaplan, Lee M.; Kastelein, John J. P.; Khaw, Kay-Tee; Knowles, Joshua W.; Kolovou, Genovefa; Kong, Augustine; Laaksonen, Reijo; Lambrechts, Diether; Leander, Karin; Lettre, Guillaume; Li, Mingyao; Lieb, Wolfgang; Loley, Christina; Lotery, Andrew J.; Mannucci, Pier M.; Maouche, Seraya; Martinelli, Nicola; McKeown, Pascal P.; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Merlini, Pier Angelica; Mooser, Vincent; Morgan, Thomas; Muehleisen, Thomas W.; Muhlestein, Joseph B.; Muenzel, Thomas; Musunuru, Kiran; nahrstaedt, Janja; Nelson, Christopher P.; Noethen, Markus M.; Olivieri, Oliviero; Patel, Riyaz S.; Patterson, Chris C.; Peters, Annette; Peyvandi, Flora; Qu, Liming; Quyyumi, Arshed A.; Rader, Daniel J.; Rallidis, Loukianos S.; Rice, Catherine; Rosendaal, Frits R.; Rubin, Diana; Salomaa, Veikko; Sampietro, M. Lourdes; Sandhu, Manj S.; Schadt, Eric; Schaefer, Arne; Schillert, Arne; Schreiber, Stefan; Schrezenmeir, Juergen; Schwartz, Stephen M.; Siscovick, David S.; Sivananthan, Mohan; Sivapalaratnam, Suthesh; Smith, Albert; Smith, Tamara B.; Snoep, Jaapjan D.; Soranzo, Nicole; Spertus, John A.; Stark, Klaus; Stirrups, Kathy; Stoll, Monika; Tang, W. H. Wilson; Tennstedt, Stephanie; Thorgeirsson, Gudmundur; Thorleifsson, Gudmar; Tomaszewski, Maciej; Uitterlinden, Andre G.; van Rij, Andre M.; Voight, Benjamin F.; Wareham, Nick J.; Wells, George A.; Wichmann, H-Erich; Wild, Philipp S.; Willenborg, Christina; Witteman, Jaqueline C. M.; Wright, Benjamin J.; Ye, Shu; Zeller, Tanja; Ziegler, Andreas; Cambien, Francois; Goodall, Alison H.; Cupples, L. Adrienne; Quertermous, Thomas; Maerz, Winfried; Hengstenberg, Christian; Blankenberg, Stefan; Ouwehand, Willem H.; Hall, Alistair S.; Deloukas, Panos; Thompson, John R.; Stefansson, Kari; Roberts, Robert; Thorsteinsdottir, Unnur; O'Donnell, Christopher J.; McPherson, Ruth; Erdmann, Jeanette; Samani, Nilesh J.

In: Nature Genetics, Vol. 43, No. 4, 2011, p. 333-U153.

Research output: Contribution to journalArticle

Harvard

Schunkert, H, Koenig, IR, Kathiresan, S, Reilly, MP, Assimes, TL, Holm, H, Preuss, M, Stewart, AFR, Barbalic, M, Gieger, C, Absher, D, Aherrahrou, Z, Allayee, H, Altshuler, D, Anand, SS, Andersen, K, Anderson, JL, Ardissino, D, Ball, SG, Balmforth, AJ, Barnes, TA, Becker, DM, Becker, LC, Berger, K, Bis, JC, Boekholdt, SM, Boerwinkle, E, Braund, PS, Brown, MJ, Burnett, MS, Buysschaert, I, Carlquist, JF, Chen, L, Cichon, S, Codd, V, Davies, RW, Dedoussis, G, Dehghan, A, Demissie, S, Devaney, JM, Diemert, P, Do, R, Doering, A, Eifert, S, El Mokhtari, NE, Ellis, SG, Elosua, R, Engert, JC, Epstein, SE, de Faire, U, Fischer, M, Folsom, AR, Freyer, J, Gigante, B, Girelli, D, Gretarsdottir, S, Gudnason, V, Gulcher, JR, Halperin, E, Hammond, N, Hazen, SL, Hofman, A, Horne, BD, Illig, T, Iribarren, C, Jones, GT, Jukema, JW, Kaiser, MA, Kaplan, LM, Kastelein, JJP, Khaw, K-T, Knowles, JW, Kolovou, G, Kong, A, Laaksonen, R, Lambrechts, D, Leander, K, Lettre, G, Li, M, Lieb, W, Loley, C, Lotery, AJ, Mannucci, PM, Maouche, S, Martinelli, N, McKeown, PP, Meisinger, C, Meitinger, T, Melander, O, Merlini, PA, Mooser, V, Morgan, T, Muehleisen, TW, Muhlestein, JB, Muenzel, T, Musunuru, K, nahrstaedt, J, Nelson, CP, Noethen, MM, Olivieri, O, Patel, RS, Patterson, CC, Peters, A, Peyvandi, F, Qu, L, Quyyumi, AA, Rader, DJ, Rallidis, LS, Rice, C, Rosendaal, FR, Rubin, D, Salomaa, V, Sampietro, ML, Sandhu, MS, Schadt, E, Schaefer, A, Schillert, A, Schreiber, S, Schrezenmeir, J, Schwartz, SM, Siscovick, DS, Sivananthan, M, Sivapalaratnam, S, Smith, A, Smith, TB, Snoep, JD, Soranzo, N, Spertus, JA, Stark, K, Stirrups, K, Stoll, M, Tang, WHW, Tennstedt, S, Thorgeirsson, G, Thorleifsson, G, Tomaszewski, M, Uitterlinden, AG, van Rij, AM, Voight, BF, Wareham, NJ, Wells, GA, Wichmann, H-E, Wild, PS, Willenborg, C, Witteman, JCM, Wright, BJ, Ye, S, Zeller, T, Ziegler, A, Cambien, F, Goodall, AH, Cupples, LA, Quertermous, T, Maerz, W, Hengstenberg, C, Blankenberg, S, Ouwehand, WH, Hall, AS, Deloukas, P, Thompson, JR, Stefansson, K, Roberts, R, Thorsteinsdottir, U, O'Donnell, CJ, McPherson, R, Erdmann, J & Samani, NJ 2011, 'Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease', Nature Genetics, vol. 43, no. 4, pp. 333-U153. https://doi.org/10.1038/ng.784

APA

Schunkert, H., Koenig, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., ... Samani, N. J. (2011). Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics, 43(4), 333-U153. https://doi.org/10.1038/ng.784

CBE

Schunkert H, Koenig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AFR, Barbalic M, Gieger C, Absher D, Aherrahrou Z, Allayee H, Altshuler D, Anand SS, Andersen K, Anderson JL, Ardissino D, Ball SG, Balmforth AJ, Barnes TA, Becker DM, Becker LC, Berger K, Bis JC, Boekholdt SM, Boerwinkle E, Braund PS, Brown MJ, Burnett MS, Buysschaert I, Carlquist JF, Chen L, Cichon S, Codd V, Davies RW, Dedoussis G, Dehghan A, Demissie S, Devaney JM, Diemert P, Do R, Doering A, Eifert S, El Mokhtari NE, Ellis SG, Elosua R, Engert JC, Epstein SE, de Faire U, Fischer M, Folsom AR, Freyer J, Gigante B, Girelli D, Gretarsdottir S, Gudnason V, Gulcher JR, Halperin E, Hammond N, Hazen SL, Hofman A, Horne BD, Illig T, Iribarren C, Jones GT, Jukema JW, Kaiser MA, Kaplan LM, Kastelein JJP, Khaw K-T, Knowles JW, Kolovou G, Kong A, Laaksonen R, Lambrechts D, Leander K, Lettre G, Li M, Lieb W, Loley C, Lotery AJ, Mannucci PM, Maouche S, Martinelli N, McKeown PP, Meisinger C, Meitinger T, Melander O, Merlini PA, Mooser V, Morgan T, Muehleisen TW, Muhlestein JB, Muenzel T, Musunuru K, nahrstaedt J, Nelson CP, Noethen MM, Olivieri O, Patel RS, Patterson CC, Peters A, Peyvandi F, Qu L, Quyyumi AA, Rader DJ, Rallidis LS, Rice C, Rosendaal FR, Rubin D, Salomaa V, Sampietro ML, Sandhu MS, Schadt E, Schaefer A, Schillert A, Schreiber S, Schrezenmeir J, Schwartz SM, Siscovick DS, Sivananthan M, Sivapalaratnam S, Smith A, Smith TB, Snoep JD, Soranzo N, Spertus JA, Stark K, Stirrups K, Stoll M, Tang WHW, Tennstedt S, Thorgeirsson G, Thorleifsson G, Tomaszewski M, Uitterlinden AG, van Rij AM, Voight BF, Wareham NJ, Wells GA, Wichmann H-E, Wild PS, Willenborg C, Witteman JCM, Wright BJ, Ye S, Zeller T, Ziegler A, Cambien F, Goodall AH, Cupples LA, Quertermous T, Maerz W, Hengstenberg C, Blankenberg S, Ouwehand WH, Hall AS, Deloukas P, Thompson JR, Stefansson K, Roberts R, Thorsteinsdottir U, O'Donnell CJ, McPherson R, Erdmann J, Samani NJ. 2011. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 43(4):333-U153. https://doi.org/10.1038/ng.784

MLA

Vancouver

Schunkert H, Koenig IR, Kathiresan S, Reilly MP, Assimes TL, Holm H et al. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nature Genetics. 2011;43(4):333-U153. https://doi.org/10.1038/ng.784

Author

Schunkert, Heribert ; Koenig, Inke R. ; Kathiresan, Sekar ; Reilly, Muredach P. ; Assimes, Themistocles L. ; Holm, Hilma ; Preuss, Michael ; Stewart, Alexandre F. R. ; Barbalic, Maja ; Gieger, Christian ; Absher, Devin ; Aherrahrou, Zouhair ; Allayee, Hooman ; Altshuler, David ; Anand, Sonia S. ; Andersen, Karl ; Anderson, Jeffrey L. ; Ardissino, Diego ; Ball, Stephen G. ; Balmforth, Anthony J. ; Barnes, Timothy A. ; Becker, Diane M. ; Becker, Lewis C. ; Berger, Klaus ; Bis, Joshua C. ; Boekholdt, S. Matthijs ; Boerwinkle, Eric ; Braund, Peter S. ; Brown, Morris J. ; Burnett, Mary Susan ; Buysschaert, Ian ; Carlquist, John F. ; Chen, Li ; Cichon, Sven ; Codd, Veryan ; Davies, Robert W. ; Dedoussis, George ; Dehghan, Abbas ; Demissie, Serkalem ; Devaney, Joseph M. ; Diemert, Patrick ; Do, Ron ; Doering, Angela ; Eifert, Sandra ; El Mokhtari, Nour Eddine ; Ellis, Stephen G. ; Elosua, Roberto ; Engert, James C. ; Epstein, Stephen E. ; de Faire, Ulf ; Fischer, Marcus ; Folsom, Aaron R. ; Freyer, Jennifer ; Gigante, Bruna ; Girelli, Domenico ; Gretarsdottir, Solveig ; Gudnason, Vilmundur ; Gulcher, Jeffrey R. ; Halperin, Eran ; Hammond, Naomi ; Hazen, Stanley L. ; Hofman, Albert ; Horne, Benjamin D. ; Illig, Thomas ; Iribarren, Carlos ; Jones, Gregory T. ; Jukema, J. Wouter ; Kaiser, Michael A. ; Kaplan, Lee M. ; Kastelein, John J. P. ; Khaw, Kay-Tee ; Knowles, Joshua W. ; Kolovou, Genovefa ; Kong, Augustine ; Laaksonen, Reijo ; Lambrechts, Diether ; Leander, Karin ; Lettre, Guillaume ; Li, Mingyao ; Lieb, Wolfgang ; Loley, Christina ; Lotery, Andrew J. ; Mannucci, Pier M. ; Maouche, Seraya ; Martinelli, Nicola ; McKeown, Pascal P. ; Meisinger, Christa ; Meitinger, Thomas ; Melander, Olle ; Merlini, Pier Angelica ; Mooser, Vincent ; Morgan, Thomas ; Muehleisen, Thomas W. ; Muhlestein, Joseph B. ; Muenzel, Thomas ; Musunuru, Kiran ; nahrstaedt, Janja ; Nelson, Christopher P. ; Noethen, Markus M. ; Olivieri, Oliviero ; Patel, Riyaz S. ; Patterson, Chris C. ; Peters, Annette ; Peyvandi, Flora ; Qu, Liming ; Quyyumi, Arshed A. ; Rader, Daniel J. ; Rallidis, Loukianos S. ; Rice, Catherine ; Rosendaal, Frits R. ; Rubin, Diana ; Salomaa, Veikko ; Sampietro, M. Lourdes ; Sandhu, Manj S. ; Schadt, Eric ; Schaefer, Arne ; Schillert, Arne ; Schreiber, Stefan ; Schrezenmeir, Juergen ; Schwartz, Stephen M. ; Siscovick, David S. ; Sivananthan, Mohan ; Sivapalaratnam, Suthesh ; Smith, Albert ; Smith, Tamara B. ; Snoep, Jaapjan D. ; Soranzo, Nicole ; Spertus, John A. ; Stark, Klaus ; Stirrups, Kathy ; Stoll, Monika ; Tang, W. H. Wilson ; Tennstedt, Stephanie ; Thorgeirsson, Gudmundur ; Thorleifsson, Gudmar ; Tomaszewski, Maciej ; Uitterlinden, Andre G. ; van Rij, Andre M. ; Voight, Benjamin F. ; Wareham, Nick J. ; Wells, George A. ; Wichmann, H-Erich ; Wild, Philipp S. ; Willenborg, Christina ; Witteman, Jaqueline C. M. ; Wright, Benjamin J. ; Ye, Shu ; Zeller, Tanja ; Ziegler, Andreas ; Cambien, Francois ; Goodall, Alison H. ; Cupples, L. Adrienne ; Quertermous, Thomas ; Maerz, Winfried ; Hengstenberg, Christian ; Blankenberg, Stefan ; Ouwehand, Willem H. ; Hall, Alistair S. ; Deloukas, Panos ; Thompson, John R. ; Stefansson, Kari ; Roberts, Robert ; Thorsteinsdottir, Unnur ; O'Donnell, Christopher J. ; McPherson, Ruth ; Erdmann, Jeanette ; Samani, Nilesh J. / Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. In: Nature Genetics. 2011 ; Vol. 43, No. 4. pp. 333-U153.

RIS

TY - JOUR

T1 - Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

AU - Schunkert, Heribert

AU - Koenig, Inke R.

AU - Kathiresan, Sekar

AU - Reilly, Muredach P.

AU - Assimes, Themistocles L.

AU - Holm, Hilma

AU - Preuss, Michael

AU - Stewart, Alexandre F. R.

AU - Barbalic, Maja

AU - Gieger, Christian

AU - Absher, Devin

AU - Aherrahrou, Zouhair

AU - Allayee, Hooman

AU - Altshuler, David

AU - Anand, Sonia S.

AU - Andersen, Karl

AU - Anderson, Jeffrey L.

AU - Ardissino, Diego

AU - Ball, Stephen G.

AU - Balmforth, Anthony J.

AU - Barnes, Timothy A.

AU - Becker, Diane M.

AU - Becker, Lewis C.

AU - Berger, Klaus

AU - Bis, Joshua C.

AU - Boekholdt, S. Matthijs

AU - Boerwinkle, Eric

AU - Braund, Peter S.

AU - Brown, Morris J.

AU - Burnett, Mary Susan

AU - Buysschaert, Ian

AU - Carlquist, John F.

AU - Chen, Li

AU - Cichon, Sven

AU - Codd, Veryan

AU - Davies, Robert W.

AU - Dedoussis, George

AU - Dehghan, Abbas

AU - Demissie, Serkalem

AU - Devaney, Joseph M.

AU - Diemert, Patrick

AU - Do, Ron

AU - Doering, Angela

AU - Eifert, Sandra

AU - El Mokhtari, Nour Eddine

AU - Ellis, Stephen G.

AU - Elosua, Roberto

AU - Engert, James C.

AU - Epstein, Stephen E.

AU - de Faire, Ulf

AU - Fischer, Marcus

AU - Folsom, Aaron R.

AU - Freyer, Jennifer

AU - Gigante, Bruna

AU - Girelli, Domenico

AU - Gretarsdottir, Solveig

AU - Gudnason, Vilmundur

AU - Gulcher, Jeffrey R.

AU - Halperin, Eran

AU - Hammond, Naomi

AU - Hazen, Stanley L.

AU - Hofman, Albert

AU - Horne, Benjamin D.

AU - Illig, Thomas

AU - Iribarren, Carlos

AU - Jones, Gregory T.

AU - Jukema, J. Wouter

AU - Kaiser, Michael A.

AU - Kaplan, Lee M.

AU - Kastelein, John J. P.

AU - Khaw, Kay-Tee

AU - Knowles, Joshua W.

AU - Kolovou, Genovefa

AU - Kong, Augustine

AU - Laaksonen, Reijo

AU - Lambrechts, Diether

AU - Leander, Karin

AU - Lettre, Guillaume

AU - Li, Mingyao

AU - Lieb, Wolfgang

AU - Loley, Christina

AU - Lotery, Andrew J.

AU - Mannucci, Pier M.

AU - Maouche, Seraya

AU - Martinelli, Nicola

AU - McKeown, Pascal P.

AU - Meisinger, Christa

AU - Meitinger, Thomas

AU - Melander, Olle

AU - Merlini, Pier Angelica

AU - Mooser, Vincent

AU - Morgan, Thomas

AU - Muehleisen, Thomas W.

AU - Muhlestein, Joseph B.

AU - Muenzel, Thomas

AU - Musunuru, Kiran

AU - nahrstaedt, Janja

AU - Nelson, Christopher P.

AU - Noethen, Markus M.

AU - Olivieri, Oliviero

AU - Patel, Riyaz S.

AU - Patterson, Chris C.

AU - Peters, Annette

AU - Peyvandi, Flora

AU - Qu, Liming

AU - Quyyumi, Arshed A.

AU - Rader, Daniel J.

AU - Rallidis, Loukianos S.

AU - Rice, Catherine

AU - Rosendaal, Frits R.

AU - Rubin, Diana

AU - Salomaa, Veikko

AU - Sampietro, M. Lourdes

AU - Sandhu, Manj S.

AU - Schadt, Eric

AU - Schaefer, Arne

AU - Schillert, Arne

AU - Schreiber, Stefan

AU - Schrezenmeir, Juergen

AU - Schwartz, Stephen M.

AU - Siscovick, David S.

AU - Sivananthan, Mohan

AU - Sivapalaratnam, Suthesh

AU - Smith, Albert

AU - Smith, Tamara B.

AU - Snoep, Jaapjan D.

AU - Soranzo, Nicole

AU - Spertus, John A.

AU - Stark, Klaus

AU - Stirrups, Kathy

AU - Stoll, Monika

AU - Tang, W. H. Wilson

AU - Tennstedt, Stephanie

AU - Thorgeirsson, Gudmundur

AU - Thorleifsson, Gudmar

AU - Tomaszewski, Maciej

AU - Uitterlinden, Andre G.

AU - van Rij, Andre M.

AU - Voight, Benjamin F.

AU - Wareham, Nick J.

AU - Wells, George A.

AU - Wichmann, H-Erich

AU - Wild, Philipp S.

AU - Willenborg, Christina

AU - Witteman, Jaqueline C. M.

AU - Wright, Benjamin J.

AU - Ye, Shu

AU - Zeller, Tanja

AU - Ziegler, Andreas

AU - Cambien, Francois

AU - Goodall, Alison H.

AU - Cupples, L. Adrienne

AU - Quertermous, Thomas

AU - Maerz, Winfried

AU - Hengstenberg, Christian

AU - Blankenberg, Stefan

AU - Ouwehand, Willem H.

AU - Hall, Alistair S.

AU - Deloukas, Panos

AU - Thompson, John R.

AU - Stefansson, Kari

AU - Roberts, Robert

AU - Thorsteinsdottir, Unnur

AU - O'Donnell, Christopher J.

AU - McPherson, Ruth

AU - Erdmann, Jeanette

AU - Samani, Nilesh J.

PY - 2011

Y1 - 2011

N2 - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

AB - We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 x 10(-8) and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.

U2 - 10.1038/ng.784

DO - 10.1038/ng.784

M3 - Article

VL - 43

SP - 333-U153

JO - Nature Genetics

JF - Nature Genetics

SN - 1546-1718

IS - 4

ER -