Leaky gut biomarkers in depression and suicidal behavior

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Leaky gut biomarkers in depression and suicidal behavior. / Ohlsson, L.; Gustafsson, A.; Lavant, E.; Suneson, K.; Brundin, L.; Westrin; Ljunggren, L.; Lindqvist, D.

In: Acta Psychiatrica Scandinavica, Vol. 139, No. 2, 2019, p. 185-193.

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Ohlsson, L. ; Gustafsson, A. ; Lavant, E. ; Suneson, K. ; Brundin, L. ; Westrin ; Ljunggren, L. ; Lindqvist, D. / Leaky gut biomarkers in depression and suicidal behavior. In: Acta Psychiatrica Scandinavica. 2019 ; Vol. 139, No. 2. pp. 185-193.

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TY - JOUR

T1 - Leaky gut biomarkers in depression and suicidal behavior

AU - Ohlsson, L.

AU - Gustafsson, A.

AU - Lavant, E.

AU - Suneson, K.

AU - Brundin, L.

AU - Westrin,

AU - Ljunggren, L.

AU - Lindqvist, D.

PY - 2019

Y1 - 2019

N2 - Objective: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. Method: We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery–Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. Results: The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = −0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). Conclusion: The ‘leaky gut hypothesis’ may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts.

AB - Objective: Inflammation is associated with major depressive disorder (MDD) and suicidal behavior. According to the ‘leaky gut hypothesis’, increased intestinal permeability may contribute to this relationship via bacterial translocation across enterocytes. We measured plasma levels of gut permeability markers, in patients with a recent suicide attempt (rSA), MDD subjects with no history of a suicide attempt (nsMDD), and healthy controls (HC), and related these markers to symptom severity and inflammation. Method: We enrolled rSA (n = 54), nsMDD (n = 13), and HC (n = 17). Zonulin, intestinal fatty acid binding protein (I-FABP), soluble CD14, and interleukin-6 (IL-6) were quantified in plasma. Montgomery–Åsberg Depression Rating Scale (MADRS) and Suicide Assessment Scale (SUAS) were used for symptom assessments. Results: The rSA group displayed higher I-FABP and lower zonulin levels compared with both the nsMDD and the HC groups (all P < 0.001). IL-6 correlated positively with I-FABP (r = 0.24, P < 0.05) and negatively with zonulin (r = −0.25, P < 0.05). In all subjects, I-FABP levels correlated positively with MADRS (r = 0.25, P < 0.05) and SUAS scores (r = 0.38, P < 0.001), and the latter correlation was significant also in the nsMDD group (r = 0.60, P < 0.05). Conclusion: The ‘leaky gut hypothesis’ may improve our understanding of the link between inflammation and suicidal behavior. These findings should be considered preliminary until replicated in larger cohorts.

KW - depressive disorder, major

KW - intestinal fatty acid binding protein

KW - intestinal permeability

KW - suicide, attempted

KW - zonulin

U2 - 10.1111/acps.12978

DO - 10.1111/acps.12978

M3 - Article

VL - 139

SP - 185

EP - 193

JO - Acta Psychiatrica Scandinavica

T2 - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 1600-0447

IS - 2

ER -