Left ventricular global wall thickness is easily calculated, detects and characterizes hypertrophy, and has prognostic utility

Research output: Contribution to conferenceAbstract

Standard

Left ventricular global wall thickness is easily calculated, detects and characterizes hypertrophy, and has prognostic utility. / Lundin, Magnus; Heiberg, Einar; Nordlund, David; Gyllenhammar, Tom; Steding Ehrenborg, Katarina; Engblom, Henrik; Carlsson, Marcus; Atar, Dan; vanderPals, Jesper; Erlinge, David; Borgquist, Rasmus; Khoshnood, Ardavan; Ekelund, Ulf; Nickander, Jannike ; Themudo, Raquel; Nordin, Sabrina; Kozor, Rebecca ; Moon, James; Maret, Eva ; Caidahl, Kenneth; Sigfridsson, Andreas; Sörensson, Peder; Schelbert, Erik B.; Arheden, Håkan; Ugander, Martin.

2019. Abstract from 20th Cardiovascular Spring Meeting, Gothenburg, Sweden.

Research output: Contribution to conferenceAbstract

Harvard

Lundin, M, Heiberg, E, Nordlund, D, Gyllenhammar, T, Steding Ehrenborg, K, Engblom, H, Carlsson, M, Atar, D, vanderPals, J, Erlinge, D, Borgquist, R, Khoshnood, A, Ekelund, U, Nickander, J, Themudo, R, Nordin, S, Kozor, R, Moon, J, Maret, E, Caidahl, K, Sigfridsson, A, Sörensson, P, Schelbert, EB, Arheden, H & Ugander, M 2019, 'Left ventricular global wall thickness is easily calculated, detects and characterizes hypertrophy, and has prognostic utility' 20th Cardiovascular Spring Meeting, Gothenburg, Sweden, 2019/04/10 - 2019/04/12, .

APA

CBE

Lundin M, Heiberg E, Nordlund D, Gyllenhammar T, Steding Ehrenborg K, Engblom H, Carlsson M, Atar D, vanderPals J, Erlinge D, Borgquist R, Khoshnood A, Ekelund U, Nickander J, Themudo R, Nordin S, Kozor R, Moon J, Maret E, Caidahl K, Sigfridsson A, Sörensson P, Schelbert EB, Arheden H, Ugander M. 2019. Left ventricular global wall thickness is easily calculated, detects and characterizes hypertrophy, and has prognostic utility. Abstract from 20th Cardiovascular Spring Meeting, Gothenburg, Sweden.

MLA

Vancouver

Author

Lundin, Magnus ; Heiberg, Einar ; Nordlund, David ; Gyllenhammar, Tom ; Steding Ehrenborg, Katarina ; Engblom, Henrik ; Carlsson, Marcus ; Atar, Dan ; vanderPals, Jesper ; Erlinge, David ; Borgquist, Rasmus ; Khoshnood, Ardavan ; Ekelund, Ulf ; Nickander, Jannike ; Themudo, Raquel ; Nordin, Sabrina ; Kozor, Rebecca ; Moon, James ; Maret, Eva ; Caidahl, Kenneth ; Sigfridsson, Andreas ; Sörensson, Peder ; Schelbert, Erik B. ; Arheden, Håkan ; Ugander, Martin. / Left ventricular global wall thickness is easily calculated, detects and characterizes hypertrophy, and has prognostic utility. Abstract from 20th Cardiovascular Spring Meeting, Gothenburg, Sweden.

RIS

TY - CONF

T1 - Left ventricular global wall thickness is easily calculated, detects and characterizes hypertrophy, and has prognostic utility

AU - Lundin, Magnus

AU - Heiberg, Einar

AU - Nordlund, David

AU - Gyllenhammar, Tom

AU - Steding Ehrenborg, Katarina

AU - Engblom, Henrik

AU - Carlsson, Marcus

AU - Atar, Dan

AU - vanderPals, Jesper

AU - Erlinge, David

AU - Borgquist, Rasmus

AU - Khoshnood, Ardavan

AU - Ekelund, Ulf

AU - Nickander, Jannike

AU - Themudo, Raquel

AU - Nordin, Sabrina

AU - Kozor, Rebecca

AU - Moon, James

AU - Maret, Eva

AU - Caidahl, Kenneth

AU - Sigfridsson, Andreas

AU - Sörensson, Peder

AU - Schelbert, Erik B.

AU - Arheden, Håkan

AU - Ugander, Martin

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Cardiovascular magnetic resonance (CMR) can be used to measure left ventricular end-diastolic volume (LVEDV) and left ventricular mass (LVM). However, there is currently no good way to measure the normality of LVM in relation to a given LVEDV. We hypothesized that a simple measure of left ventricular global wall thickness (GWT) would be accurate, beneficial for detecting and characterizing hypertrophy, and have prognostic significance.METHODS: Subjects underwent CMR at 1.5T, including healthy volunteers (n=99) and patients assessed for heart disease (n=2828).RESULTS: GWT calculated from LVEDV and LVM had excellent agreement with measured mean end-diastolic wall thickness of the entire left ventricle (bias 0.01±0.23mm). GWT was most predictive of death or hospitalization for heart failure in patients with normal findings by CMR (n=326, log-rank 26.8, p<0.001, median [interquartile range] follow-up 5.8 [5.0–6.7] years). GWT indexed to body surface area (GWTi) was most predictive of outcomes in patients with normal LVEDV index (n=1352, log-rank 36.4, p<0.001, follow-up 5.5 [4.1–6.5] years). Patients with concentric remodeling had worse prognosis than the normal patients (p=0.02), and the patients with hypertrophy had worse prognosis than both normal patients (p<0.001) and patients with concentric remodeling (p=0.045), see Figure 1. Of patients with suspected heart disease but normal CMR findings regarding left ventricular volumes, function, mass, and scar, 22% were found to have increased mean GWTi corresponding to concentric remodeling, see Figure 2.CONCLUSIONS: Left ventricular GWT is an intuitive measure that can be easily calculated from mass and volume with high accuracy, and has prognostic utility in patients with normal CMR findings. Also, GWTi classifies hypertrophy as concentric or eccentric, and detects concentric remodeling in a substantial portion of patients with otherwise normal findings.

AB - BACKGROUND: Cardiovascular magnetic resonance (CMR) can be used to measure left ventricular end-diastolic volume (LVEDV) and left ventricular mass (LVM). However, there is currently no good way to measure the normality of LVM in relation to a given LVEDV. We hypothesized that a simple measure of left ventricular global wall thickness (GWT) would be accurate, beneficial for detecting and characterizing hypertrophy, and have prognostic significance.METHODS: Subjects underwent CMR at 1.5T, including healthy volunteers (n=99) and patients assessed for heart disease (n=2828).RESULTS: GWT calculated from LVEDV and LVM had excellent agreement with measured mean end-diastolic wall thickness of the entire left ventricle (bias 0.01±0.23mm). GWT was most predictive of death or hospitalization for heart failure in patients with normal findings by CMR (n=326, log-rank 26.8, p<0.001, median [interquartile range] follow-up 5.8 [5.0–6.7] years). GWT indexed to body surface area (GWTi) was most predictive of outcomes in patients with normal LVEDV index (n=1352, log-rank 36.4, p<0.001, follow-up 5.5 [4.1–6.5] years). Patients with concentric remodeling had worse prognosis than the normal patients (p=0.02), and the patients with hypertrophy had worse prognosis than both normal patients (p<0.001) and patients with concentric remodeling (p=0.045), see Figure 1. Of patients with suspected heart disease but normal CMR findings regarding left ventricular volumes, function, mass, and scar, 22% were found to have increased mean GWTi corresponding to concentric remodeling, see Figure 2.CONCLUSIONS: Left ventricular GWT is an intuitive measure that can be easily calculated from mass and volume with high accuracy, and has prognostic utility in patients with normal CMR findings. Also, GWTi classifies hypertrophy as concentric or eccentric, and detects concentric remodeling in a substantial portion of patients with otherwise normal findings.

KW - MRI

KW - Magnetic Resonance Imaging

KW - Hyperthrophy

M3 - Abstract

ER -