Left ventricular hypertrophy in adults with previous repair of coarctation of the aorta; Association with systolic blood pressure in the high normal range

Research output: Contribution to journalArticle

Abstract

Background Arterial hypertension is common in adults with repaired coarctation of the aorta (CoA). The associations between the diagnosis of hypertension, actual blood pressure, other factors affecting left ventricular overload, and left ventricular hypertrophy (LVH) are not yet fully explored in this population. Material and results From the national register for congenital heart disease, 506 adult patients (≥ 18 years old) with previous repair of CoA were identified (37.0% female, mean age 35.7 ± 13.8 years, with an average of 26.8 ± 12.4 years post repair). Echocardiographic data were available for all patients, and showed LVH in 114 (22.5%) of these. Systolic blood pressure (SBP) (mm Hg) (OR 1.02, CI 1.01-1.04), aortic valve disease, (OR 2.17, CI 1.33-3.53), age (years) (OR 1.03, CI 1.01-1.05), diagnosis of arterial hypertension (OR 3.02, CI 1.81-5.02), and sex (female) (OR 0.41, CI 0.24-0.72) were independently associated with LVH. There was an association with LVH at SBP within the upper reference limits [130, 140] mm Hg (OR 2.23, CI 1.05-4.73) that further increased for SBP > 140 mm Hg (OR 8.02, CI 3.76-17.12). Conclusions LVH is common post repair of CoA and is associated with SBP even below the currently recommended target level. Lower target levels may therefore become justified in this population. ORCID Id: 0000-0003-0976-6910.

Details

Authors
  • Daniel Rinnström
  • Mikael Dellborg
  • Ulf Thilén
  • Peder Sörensson
  • Niels Eric Nielsen
  • Christina Christersson
  • Bengt Johansson
Organisations
External organisations
  • Umeå University
  • University of Gothenburg
  • Karolinska Institutet
  • Linköping University
  • Uppsala University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • Adult congenital heart disease, CoA, Hypertension, Left ventricular hypertrophy
Original languageEnglish
Pages (from-to)59-64
Number of pages6
JournalInternational Journal of Cardiology
Volume218
Publication statusPublished - 2016 Sep 1
Publication categoryResearch
Peer-reviewedYes