Levodopa infusion in Parkinson's disease: Individual quality of life

Research output: Contribution to journalArticle

Abstract

Objectives: Parkinson's disease (PD) features both motor and non-motor symptoms that substantially impact quality of life (QoL). Levodopa-carbidopa intestinal gel (LCIG) reduces motor complications and improves some non-motor symptoms in advanced PD (APD). Change in patients' health-related quality of life (hrQoL) is a common endpoint in PD trials and has become an important factor in judging overall effect of LCIG. However, hrQoL is considered to be only one dimension of QoL. The primary aim of this prospective observational study was to observe the effects of LCIG on individual quality of life (iQoL) in PD and caregivers. The secondary aim was to investigate its effects on patients' motor and non-motor symptoms as well as effects on caregiver burden. Materials & Methods: Utilizing the Schedule for the Evaluation of Individual Quality of Life-Questionnaire (SEIQoL-Q) and the Personal Wellbeing Index-Adult (PWI-A), twelve patients with advanced PD and their caregivers were followed for six months after initiation of LCIG treatment. Results: At the final follow-up, improvements of iQoL for patients (median SEIQoL index improvement 0.16, P <.05) and caregivers (median SEIQoL index improvement 0.20, P <.05) were seen together with improvements of motor and non-motor symptoms. There were no significant improvements of hrQoL. Conclusions: The study results indicate that LCIG improves iQoL in PD in addition to the improvement of motor and non-motor symptoms. Furthermore, this study signals that LCIG may also contribute to improvement of iQoL in caregivers.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • Central Hospital Bremerhaven
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • caregiver, disease, duodenum, infusion, non-motor, Parkinson's, quality of life
Original languageEnglish
Pages (from-to)248-254
Number of pages7
JournalActa Neurologica Scandinavica
Volume142
Issue number3
Early online date2020 May 7
Publication statusPublished - 2020 Sep
Publication categoryResearch
Peer-reviewedYes