Lim Domain Binding 2: A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis.

Research output: Contribution to journalArticle


Using a multitissue, genome-wide gene expression approach, we recently identified a gene module linked to the extent of human atherosclerosis. This atherosclerosis module was enriched with inherited risk for coronary and carotid artery disease (CAD) and overlapped with genes in the transendothelial migration of leukocyte (TEML) pathway. Among the atherosclerosis module genes, the transcription cofactor Lim domain binding 2 (LDB2) was the most connected in a CAD vascular wall regulatory gene network. Here, we used human genomics and atherosclerosis-prone mice to evaluate the possible role of LDB2 in TEML and atherosclerosis.


  • Ming-Mei Shang
  • Husain A Talukdar
  • Jennifer J Hofmann
  • Colin Niaudet
  • Hassan Foroughi Asl
  • Rajeev K Jain
  • Aranzazu Rossignoli
  • Cecilia Cedergren
  • Angela Silveira
  • Bruna Gigante
  • Karin Leander
  • Ulf de Faire
  • Anders Hamsten
  • Arno Ruusalepp
  • Torbjörn Ivert
  • Tom Michoel
  • Eric E Schadt
  • Christer Betsholtz
  • Josefin Skogsberg
  • Johan L M Björkegren
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)2068-2077
JournalArteriosclerosis, Thrombosis and Vascular Biology
Issue number9
Publication statusPublished - 2014
Publication categoryResearch