Lipoprotein deficient serum stimulates the uptake of chylomicron remnants in cultured hepatocytes

Research output: Contribution to journalArticle

Abstract

Rat hepatocyte monolayers were cultured in the presence of 1-10% lipoprotein-deficient foetal calf serum. This increased the uptake and degradation of chylomicron remnant cholesteryl ester significantly. The increase occurred at all cell densities, i.e. also with less dense cultures where the basal rate of uptake per mg protein was highest. This indicates that tissue culture medium content of lipoprotein cholesterol can regulate the uptake of chylomicron remnants in hepatocytes, analogous to the regulation of the LDL receptor in extrahepatic cell.

Details

Authors
External organisations
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical and Health Sciences
Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalScandinavian Journal of Clinical & Laboratory Investigation
Volume48
Issue number6
Publication statusPublished - 1988 Oct 1
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes