Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer's Disease and Dementia: Results from the Betula Cohort in Northern Sweden

Research output: Contribution to journalReview article


Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1µg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.


External organisations
  • Umeå University
  • Swedish Meteorological and Hydrological Institute
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health


  • Air pollution, Alzheimer's disease, dementia, particulate air pollution, PM
Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalJournal of Alzheimer's Disease
Issue number1
Publication statusPublished - 2021
Publication categoryResearch

Bibliographic note

Funding Information: This work was supported by Swedish Research Council Formas under grant agreement number 2017-00898 (AO).