Location and nature of the residues important for ligand recognition in G-protein coupled receptors

Research output: Contribution to journalReview article

Abstract

The overall structure of the biogenic amine subclass of the G-protein-coupled receptors, and of their ligand binding sites, is discussed with the aim of highlighting the major structural features of these receptors that are responsible for ligand recognition. A comparison is made between biogenic amine receptors, peptide receptors of the rhodopsin class, and the secretin receptors which all have peptide ligands. The question of where the peptide ligands bind, whether at extracellular sites or within the transmembrane helix bundle, is discussed. The suitability of the rhodopsin crystal structure as a template for construction of homology models is discussed and it is concluded that there are many reasons why a caution should be issued against using it uncritically.

Details

Authors
  • Robert P. Bywater
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • ligand binding site, ligand binding residue, receptor, GPCR, antitarget, target
Original languageEnglish
Pages (from-to)60-72
JournalJournal of Molecular Recognition
Volume18
Issue number1
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes