Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder

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Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder. / Khan, Maryam S.; Wu, Gwyneth W.Y.; Reus, Victor I.; Hough, Christina M.; Lindqvist, Daniel; Westrin, Åsa; Nier, Brenton M.; Wolkowitz, Owen M.; Mellon, Synthia H.

In: Psychiatry Research, Vol. 273, 2019, p. 108-113.

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Khan, Maryam S. ; Wu, Gwyneth W.Y. ; Reus, Victor I. ; Hough, Christina M. ; Lindqvist, Daniel ; Westrin, Åsa ; Nier, Brenton M. ; Wolkowitz, Owen M. ; Mellon, Synthia H. / Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder. In: Psychiatry Research. 2019 ; Vol. 273. pp. 108-113.

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TY - JOUR

T1 - Low serum brain-derived neurotrophic factor is associated with suicidal ideation in major depressive disorder

AU - Khan, Maryam S.

AU - Wu, Gwyneth W.Y.

AU - Reus, Victor I.

AU - Hough, Christina M.

AU - Lindqvist, Daniel

AU - Westrin, Åsa

AU - Nier, Brenton M.

AU - Wolkowitz, Owen M.

AU - Mellon, Synthia H.

PY - 2019

Y1 - 2019

N2 - The “neurotrophic hypothesis of depression” posits that low levels of brain-derived neurotrophic factor (BDNF) are associated with Major Depressive Disorder (MDD). Low levels of BDNF have also been found in individuals with suicide attempts, in MDD or other disorders, suggesting that low BDNF may also be associated with suicidality. We assessed serum BDNF in 68 physically healthy and unmedicated (for at least 6 weeks) MDD subjects, who expressed no suicidal ideation (NSI; N = 40) or endorsed suicidal ideation (SI; N = 28), but were not actively suicidal, and in healthy controls (HC; N = 76). Serum BDNF levels were significantly lower in MDD with SI compared to NSI MDD but were not significantly correlated with total Hamilton Depression Rating Scale (HDRS-17) severity or severity on any HDRS subscale. Covarying for age, sex, body mass index, platelets, perceived stress, smoking and physical activity did not alter the significant association between BDNF and SI. SI status was not significantly different between HC and MDD. Our findings show an association between low serum BDNF and SI in individuals with less than severe and non-active suicidal intent, suggesting that the individual symptom of suicidality may extend the neurotrophic hypothesis of depression to include suicidal ideation within MDD.

AB - The “neurotrophic hypothesis of depression” posits that low levels of brain-derived neurotrophic factor (BDNF) are associated with Major Depressive Disorder (MDD). Low levels of BDNF have also been found in individuals with suicide attempts, in MDD or other disorders, suggesting that low BDNF may also be associated with suicidality. We assessed serum BDNF in 68 physically healthy and unmedicated (for at least 6 weeks) MDD subjects, who expressed no suicidal ideation (NSI; N = 40) or endorsed suicidal ideation (SI; N = 28), but were not actively suicidal, and in healthy controls (HC; N = 76). Serum BDNF levels were significantly lower in MDD with SI compared to NSI MDD but were not significantly correlated with total Hamilton Depression Rating Scale (HDRS-17) severity or severity on any HDRS subscale. Covarying for age, sex, body mass index, platelets, perceived stress, smoking and physical activity did not alter the significant association between BDNF and SI. SI status was not significantly different between HC and MDD. Our findings show an association between low serum BDNF and SI in individuals with less than severe and non-active suicidal intent, suggesting that the individual symptom of suicidality may extend the neurotrophic hypothesis of depression to include suicidal ideation within MDD.

KW - BDNF

KW - Depression

KW - Suicide

U2 - 10.1016/j.psychres.2019.01.013

DO - 10.1016/j.psychres.2019.01.013

M3 - Article

VL - 273

SP - 108

EP - 113

JO - Psychiatry Research

T2 - Psychiatry Research

JF - Psychiatry Research

SN - 1872-7123

ER -