Low total cholesterol and low-density lipoprotein associated with aggression and hostility in recent suicide attempters
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Low total cholesterol and low-density lipoprotein associated with aggression and hostility in recent suicide attempters. / Suneson, Klara; Asp, Marie; Träskman-Bendz, Lil; Westrin, Åsa; Ambrus, Livia; Lindqvist, Daniel.
In: Psychiatry Research, Vol. 273, 2019, p. 430-434.Research output: Contribution to journal › Article
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T1 - Low total cholesterol and low-density lipoprotein associated with aggression and hostility in recent suicide attempters
AU - Suneson, Klara
AU - Asp, Marie
AU - Träskman-Bendz, Lil
AU - Westrin, Åsa
AU - Ambrus, Livia
AU - Lindqvist, Daniel
PY - 2019
Y1 - 2019
N2 - Low cholesterol levels have been correlated with both suicidal and aggressive behavior in psychiatric patients. Few studies have investigated associations between serum lipid profiles and both aggressive state and trait. Fifty-two psychiatric medication-free inpatients were included in this study after a suicide attempt. Composite scores of “State Aggression” and “Trait Aggression” were calculated using relevant items from the Comprehensive Psychopathological Rating Scale and the Karolinska Scales of Personality. State Aggression was significantly and negatively correlated with total cholesterol (TC) and low-density lipoprotein (LDL). Trait Aggression was also significantly and negatively correlated with LDL, but not TC. There were small but significant mediation effects of severity of anxiety symptoms on the relationship between State Aggression and TC as well as LDL. In exploratory analyses we found that low cholesterol was also associated with personality traits of hostility. Moreover, low cholesterol was more robustly associated with personality trait items related to interpersonal aggression, as opposed to items related to irritability or more indirect, non-overt aggression. Our findings suggest that low cholesterol is associated with both state and trait aggression in suicide attempters. Future mechanistic studies are warranted to better understand the relationship between low cholesterol and high aggression in suicide attempters.
AB - Low cholesterol levels have been correlated with both suicidal and aggressive behavior in psychiatric patients. Few studies have investigated associations between serum lipid profiles and both aggressive state and trait. Fifty-two psychiatric medication-free inpatients were included in this study after a suicide attempt. Composite scores of “State Aggression” and “Trait Aggression” were calculated using relevant items from the Comprehensive Psychopathological Rating Scale and the Karolinska Scales of Personality. State Aggression was significantly and negatively correlated with total cholesterol (TC) and low-density lipoprotein (LDL). Trait Aggression was also significantly and negatively correlated with LDL, but not TC. There were small but significant mediation effects of severity of anxiety symptoms on the relationship between State Aggression and TC as well as LDL. In exploratory analyses we found that low cholesterol was also associated with personality traits of hostility. Moreover, low cholesterol was more robustly associated with personality trait items related to interpersonal aggression, as opposed to items related to irritability or more indirect, non-overt aggression. Our findings suggest that low cholesterol is associated with both state and trait aggression in suicide attempters. Future mechanistic studies are warranted to better understand the relationship between low cholesterol and high aggression in suicide attempters.
KW - Biological
KW - Lipids
KW - Personality
KW - Psychiatry
U2 - 10.1016/j.psychres.2019.01.056
DO - 10.1016/j.psychres.2019.01.056
M3 - Article
C2 - 30684788
AN - SCOPUS:85060296708
VL - 273
SP - 430
EP - 434
JO - Psychiatry Research
JF - Psychiatry Research
SN - 1872-7123
ER -