Lower breast cancer survival in mothers of children with a malignancy: a national study.
Research output: Contribution to journal › Article
As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||British Journal of Cancer|
|Publication status||Published - 2008|
Related research output
Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutationsSusanne Magnusson, 2012, Department of Oncology, Clinical Sciences, Lund University. 135 p.
Research output: Thesis › Doctoral Thesis (compilation)