Lower breast cancer survival in mothers of children with a malignancy: a national study.

Research output: Contribution to journalArticle

Abstract

As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)1876-1878
JournalBritish Journal of Cancer
Volume98
Issue number11
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes

Related research output

Susanne Magnusson, 2012, Department of Oncology, Clinical Sciences, Lund University. 135 p.

Research output: ThesisDoctoral Thesis (compilation)

View all (1)