Lower breast cancer survival in mothers of children with a malignancy: a national study.

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Lower breast cancer survival in mothers of children with a malignancy: a national study. / Olsson, Håkan; Magnusson, Susanne; Bladström, Anna.

In: British Journal of Cancer, Vol. 98, No. 11, 2008, p. 1876-1878.

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Olsson, Håkan ; Magnusson, Susanne ; Bladström, Anna. / Lower breast cancer survival in mothers of children with a malignancy: a national study. In: British Journal of Cancer. 2008 ; Vol. 98, No. 11. pp. 1876-1878.

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TY - JOUR

T1 - Lower breast cancer survival in mothers of children with a malignancy: a national study.

AU - Olsson, Håkan

AU - Magnusson, Susanne

AU - Bladström, Anna

PY - 2008

Y1 - 2008

N2 - As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival.

AB - As it is unclear if hereditary factors affect breast cancer survival, this was compared using fertility and cancer registry data, among all women so diagnosed during 1961-1999 in Sweden, having a child with childhood cancer (<or=20 years of age; n=254) and with that of other women (n=74,781). Those having a child with a childhood malignancy had a significantly worse survival than other women, relative risk (RR)=1.25, 95% CI 1.02-1.55, P<0.04, adjusted for age at diagnosis, year of diagnosis, parity and time since last pregnancy. Childhood sarcomas or acute myeloid leukaemia seemed to be most associated with a worse survival in the mother (RR=1.38 and 1.69, respectively). The lower survival of the mother was present for breast cancer diagnosed both before and after 50 years of age. The Li-Fraumeni syndrome and possibly other genetic disorders may lower breast cancer survival.

U2 - 10.1038/sj.bjc.6604350

DO - 10.1038/sj.bjc.6604350

M3 - Article

VL - 98

SP - 1876

EP - 1878

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 1532-1827

IS - 11

ER -