LRRK2 variation and Parkinson's disease in African Americans

Research output: Contribution to journalArticle

Abstract

The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding variations; however, there did not appear to be any frequent (>5%) pathogenic mutations. Given the ethnic-specific LRRK2 variation previously identified in PD further studies in under-represented populations are warranted.

Details

Authors
  • Owen A. Ross
  • Greggory J. Wilhoite
  • Justin A. Bacon
  • Alexandra I. Soto-Ortolaza
  • Jennifer Kachergus
  • Stephanie A Cobb
  • Andreas Puschmann
  • Carles Vilariño-Güell
  • Matthew J. Farrer
  • Neill R Graff-Radford
  • James F. Meschia
  • Zbigniew K Wszolek
Organisations
External organisations
  • Mayo Clinic Minnesota
Research areas and keywords

Keywords

  • Genetics, Leucine-rich repeat kinase 2, Parkinsonism
Original languageEnglish
Pages (from-to)1973-1992
Number of pages20
JournalMovement Disorders
Volume25
Issue number12
Publication statusPublished - 2010 Sep 15
Publication categoryResearch
Peer-reviewedYes