l-Serine synthesis in the central nervous system: A review on serine deficiency disorders
Research output: Contribution to journal › Review article
The de novo synthesis of the amino acid l-serine plays an essential role in the development and functioning of the central nervous system (CNS). l-Serine displays many metabolic functions during different developmental stages; among its functions providing precursors for amino acids, protein synthesis, nucleotide synthesis, neurotransmitter synthesis and l-serine derived lipids. Patients with congenital defects in the l-serine synthesizing enzymes present with severe neurological abnormalities and underscore the importance of this synthetic pathway. In this review, we will discuss the cellular functions of the l-serine pathway, structure and enzymatic properties of the enzymes involved and genetic defects associated with this pathway.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Molecular Genetics and Metabolism|
|Publication status||Published - 2010 Mar 1|