Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.

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Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells. / Böiers, Charlotta; Carrelha, Joana; Lutteropp, Michael; Luc, Sidinh; Green, Joanna C A; Azzoni, Emanuele; Woll, Petter S; Mead, Adam J; Hultquist, Anne; Swiers, Gemma; Perdiguero, Elisa Gomez; Macaulay, Iain C; Melchiori, Luca; Luis, Tiago C; Kharazi, Shabnam; Bouriez-Jones, Tiphaine; Deng, Qiaolin; Pontén, Annica; Atkinson, Deborah; Jensen, Christina; Sitnicka Quinn, Ewa; Geissmann, Frederic; Godin, Isabelle; Sandberg, Rickard; de Bruijn, Marella F T R; Jacobsen, Sten Eirik W.

In: Cell Stem Cell, Vol. 13, No. 5, 2013, p. 535-548.

Research output: Contribution to journalArticle

Harvard

Böiers, C, Carrelha, J, Lutteropp, M, Luc, S, Green, JCA, Azzoni, E, Woll, PS, Mead, AJ, Hultquist, A, Swiers, G, Perdiguero, EG, Macaulay, IC, Melchiori, L, Luis, TC, Kharazi, S, Bouriez-Jones, T, Deng, Q, Pontén, A, Atkinson, D, Jensen, C, Sitnicka Quinn, E, Geissmann, F, Godin, I, Sandberg, R, de Bruijn, MFTR & Jacobsen, SEW 2013, 'Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.', Cell Stem Cell, vol. 13, no. 5, pp. 535-548. https://doi.org/10.1016/j.stem.2013.08.012

APA

CBE

Böiers C, Carrelha J, Lutteropp M, Luc S, Green JCA, Azzoni E, Woll PS, Mead AJ, Hultquist A, Swiers G, Perdiguero EG, Macaulay IC, Melchiori L, Luis TC, Kharazi S, Bouriez-Jones T, Deng Q, Pontén A, Atkinson D, Jensen C, Sitnicka Quinn E, Geissmann F, Godin I, Sandberg R, de Bruijn MFTR, Jacobsen SEW. 2013. Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells. Cell Stem Cell. 13(5):535-548. https://doi.org/10.1016/j.stem.2013.08.012

MLA

Vancouver

Author

Böiers, Charlotta ; Carrelha, Joana ; Lutteropp, Michael ; Luc, Sidinh ; Green, Joanna C A ; Azzoni, Emanuele ; Woll, Petter S ; Mead, Adam J ; Hultquist, Anne ; Swiers, Gemma ; Perdiguero, Elisa Gomez ; Macaulay, Iain C ; Melchiori, Luca ; Luis, Tiago C ; Kharazi, Shabnam ; Bouriez-Jones, Tiphaine ; Deng, Qiaolin ; Pontén, Annica ; Atkinson, Deborah ; Jensen, Christina ; Sitnicka Quinn, Ewa ; Geissmann, Frederic ; Godin, Isabelle ; Sandberg, Rickard ; de Bruijn, Marella F T R ; Jacobsen, Sten Eirik W. / Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells. In: Cell Stem Cell. 2013 ; Vol. 13, No. 5. pp. 535-548.

RIS

TY - JOUR

T1 - Lymphomyeloid Contribution of an Immune-Restricted Progenitor Emerging Prior to Definitive Hematopoietic Stem Cells.

AU - Böiers, Charlotta

AU - Carrelha, Joana

AU - Lutteropp, Michael

AU - Luc, Sidinh

AU - Green, Joanna C A

AU - Azzoni, Emanuele

AU - Woll, Petter S

AU - Mead, Adam J

AU - Hultquist, Anne

AU - Swiers, Gemma

AU - Perdiguero, Elisa Gomez

AU - Macaulay, Iain C

AU - Melchiori, Luca

AU - Luis, Tiago C

AU - Kharazi, Shabnam

AU - Bouriez-Jones, Tiphaine

AU - Deng, Qiaolin

AU - Pontén, Annica

AU - Atkinson, Deborah

AU - Jensen, Christina

AU - Sitnicka Quinn, Ewa

AU - Geissmann, Frederic

AU - Godin, Isabelle

AU - Sandberg, Rickard

AU - de Bruijn, Marella F T R

AU - Jacobsen, Sten Eirik W

PY - 2013

Y1 - 2013

N2 - In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.

AB - In jawed vertebrates, development of an adaptive immune-system is essential for protection of the born organism against otherwise life-threatening pathogens. Myeloid cells of the innate immune system are formed early in development, whereas lymphopoiesis has been suggested to initiate much later, following emergence of definitive hematopoietic stem cells (HSCs). Herein, we demonstrate that the embryonic lymphoid commitment process initiates earlier than previously appreciated, prior to emergence of definitive HSCs, through establishment of a previously unrecognized entirely immune-restricted and lymphoid-primed progenitor. Notably, this immune-restricted progenitor appears to first emerge in the yolk sac and contributes physiologically to the establishment of lymphoid and some myeloid components of the immune-system, establishing the lymphomyeloid lineage restriction process as an early and physiologically important lineage-commitment step in mammalian hematopoiesis.

U2 - 10.1016/j.stem.2013.08.012

DO - 10.1016/j.stem.2013.08.012

M3 - Article

VL - 13

SP - 535

EP - 548

JO - Cell Stem Cell

T2 - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 5

ER -