Macroscopic findings in collagenous colitis: A multi-center, retrospective, observational cohort study

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Macroscopic findings in collagenous colitis : A multi-center, retrospective, observational cohort study. / Koulaouzidis, Anastasios; Yung, Diana E; Nemeth, Artur; Sjöberg, Klas; Giannakou, Andry; Qureshi, Raheel; Bartzis, Leonidas; McNeill, Morna; Johansson, Gabriele Wurm; Lucendo, Alfredo J.; Fineron, Paul; Trimble, Ken C.; Saeed, Athar; Plevris, John N; Toth, Ervin.

In: Annals of Gastroenterology, Vol. 30, No. 3, 2017, p. 309-314.

Research output: Contribution to journalArticle

Harvard

Koulaouzidis, A, Yung, DE, Nemeth, A, Sjöberg, K, Giannakou, A, Qureshi, R, Bartzis, L, McNeill, M, Johansson, GW, Lucendo, AJ, Fineron, P, Trimble, KC, Saeed, A, Plevris, JN & Toth, E 2017, 'Macroscopic findings in collagenous colitis: A multi-center, retrospective, observational cohort study', Annals of Gastroenterology, vol. 30, no. 3, pp. 309-314. https://doi.org/10.20524/aog.2017.0131

APA

CBE

Koulaouzidis A, Yung DE, Nemeth A, Sjöberg K, Giannakou A, Qureshi R, Bartzis L, McNeill M, Johansson GW, Lucendo AJ, Fineron P, Trimble KC, Saeed A, Plevris JN, Toth E. 2017. Macroscopic findings in collagenous colitis: A multi-center, retrospective, observational cohort study. Annals of Gastroenterology. 30(3):309-314. https://doi.org/10.20524/aog.2017.0131

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Author

Koulaouzidis, Anastasios ; Yung, Diana E ; Nemeth, Artur ; Sjöberg, Klas ; Giannakou, Andry ; Qureshi, Raheel ; Bartzis, Leonidas ; McNeill, Morna ; Johansson, Gabriele Wurm ; Lucendo, Alfredo J. ; Fineron, Paul ; Trimble, Ken C. ; Saeed, Athar ; Plevris, John N ; Toth, Ervin. / Macroscopic findings in collagenous colitis : A multi-center, retrospective, observational cohort study. In: Annals of Gastroenterology. 2017 ; Vol. 30, No. 3. pp. 309-314.

RIS

TY - JOUR

T1 - Macroscopic findings in collagenous colitis

T2 - A multi-center, retrospective, observational cohort study

AU - Koulaouzidis, Anastasios

AU - Yung, Diana E

AU - Nemeth, Artur

AU - Sjöberg, Klas

AU - Giannakou, Andry

AU - Qureshi, Raheel

AU - Bartzis, Leonidas

AU - McNeill, Morna

AU - Johansson, Gabriele Wurm

AU - Lucendo, Alfredo J.

AU - Fineron, Paul

AU - Trimble, Ken C.

AU - Saeed, Athar

AU - Plevris, John N

AU - Toth, Ervin

PY - 2017

Y1 - 2017

N2 - Background Collagenous colitis (CC) is by definition a histological diagnosis. However, colonoscopy often reveals characteristic endoscopic findings. The aim of this study was to evaluate the frequency and type of endoscopic findings in patients diagnosed with CC in 4 participating centers. Methods This was a retrospective study; the databases of 2 university hospitals in Edinburgh (Scotland) and Malmö (Sweden), and 2 district general hospitals in Tomelloso (Spain) and Gateshead (England) were interrogated for patients diagnosed with CC between May 2008 and August 2013. Endoscopy reports and images were retrieved and reviewed; data on lesions, sedation, bowel preparation and endoscopist experience were abstracted. Categorical data are reported as mean±SD. Fischer’s exact, chi-square and t (unpaired) tests were used to compare datasets. A two-tailed P-value of <0.05 was considered statistically significant. Results 607 patients (149 male, mean age 66.9±12.25 years) were diagnosed with CC. A total of 108/607 (17.8%) patients had one or more suggestive endoscopy findings: i.e., mucosal erythema/edema, 91/607 (15%); linear colonic mucosal defects, 12/607 (2%); or mucosal scarring, 5/607 (0.82%). For colonic mucosa erythema, there was no difference in the odds of finding erythema with the use of different bowel preparation methods (P=0.997). For colonic mucosal defects there was some evidence (P=0.005) that patients colonoscoped by experienced endoscopists had 87% less odds of developing such defects. Moreover, there was evidence that analgesia reduced the odds of developing mucosal defects by 84%. Conclusion A significant minority of patients with CC have endoscopic findings in colonoscopy. The description of such findings appears to be related to the endoscopist’s experience.

AB - Background Collagenous colitis (CC) is by definition a histological diagnosis. However, colonoscopy often reveals characteristic endoscopic findings. The aim of this study was to evaluate the frequency and type of endoscopic findings in patients diagnosed with CC in 4 participating centers. Methods This was a retrospective study; the databases of 2 university hospitals in Edinburgh (Scotland) and Malmö (Sweden), and 2 district general hospitals in Tomelloso (Spain) and Gateshead (England) were interrogated for patients diagnosed with CC between May 2008 and August 2013. Endoscopy reports and images were retrieved and reviewed; data on lesions, sedation, bowel preparation and endoscopist experience were abstracted. Categorical data are reported as mean±SD. Fischer’s exact, chi-square and t (unpaired) tests were used to compare datasets. A two-tailed P-value of <0.05 was considered statistically significant. Results 607 patients (149 male, mean age 66.9±12.25 years) were diagnosed with CC. A total of 108/607 (17.8%) patients had one or more suggestive endoscopy findings: i.e., mucosal erythema/edema, 91/607 (15%); linear colonic mucosal defects, 12/607 (2%); or mucosal scarring, 5/607 (0.82%). For colonic mucosa erythema, there was no difference in the odds of finding erythema with the use of different bowel preparation methods (P=0.997). For colonic mucosal defects there was some evidence (P=0.005) that patients colonoscoped by experienced endoscopists had 87% less odds of developing such defects. Moreover, there was evidence that analgesia reduced the odds of developing mucosal defects by 84%. Conclusion A significant minority of patients with CC have endoscopic findings in colonoscopy. The description of such findings appears to be related to the endoscopist’s experience.

KW - Colonoscopy

KW - Endoscopist training

KW - Macroscopic findings

KW - Microscopic colitis

KW - Observational study

UR - http://www.scopus.com/inward/record.url?scp=85018334665&partnerID=8YFLogxK

U2 - 10.20524/aog.2017.0131

DO - 10.20524/aog.2017.0131

M3 - Article

VL - 30

SP - 309

EP - 314

JO - Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology

JF - Annals of gastroenterology : quarterly publication of the Hellenic Society of Gastroenterology

SN - 1108-7471

IS - 3

ER -