Male gender is an adverse prognostic factor in B-cell lymphoma patients treated with immunochemotherapy

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Abstract

Male gender is an adverse prognostic factor in Hodgkin's lymphoma, but no such association has yet been established in non-Hodgkin lymphomas. Here, we have evaluated whether gender has prognostic impact on the survival of patients with B-cell non-Hodgkin lymphoma in the postrituximab era of lymphoma therapies. The study populations consisted of 217 diffuse large B-cell lymphoma (DLBCL) and 110 follicular lymphoma (FL) patients treated with immunochemotherapy. Hundred and sixty chemotherapy-treated DLBCL patients served as a control group. According to Kaplan-Meier analyses, female patients had a significantly better progression-free survival than men both in DLBCL (4 yr PFS 75% vs. 60%; P = 0.013) and in FL (4 yr PFS 68% vs. 52%, P = 0.036) patients treated with immunochemotherapy. In chemotherapy-treated DLBCL patients, no difference in survival between the genders was found. The results support the idea that women seem to respond better to rituximab.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology

Keywords

  • B-cell non-Hodgkin lymphoma, prognostic factors, gender, immunochemotherapy
Original languageEnglish
Pages (from-to)124-128
JournalEuropean Journal of Haematology
Volume86
Issue number2
Publication statusPublished - 2011
Publication categoryResearch
Peer-reviewedYes