Mass spectrometry of peptides in neuroscience

Research output: Contribution to journalReview article

Abstract

This review focuses on the contributions of modern mass spectrometry to neuropeptide research. An introduction to newer mass spectrometric techniques is provided. Also, the use of mass spectrometry in combination with high-resolution separation techniques for neuropeptide identification in biological samples is illustrated. The amino acid sequence information that is important for the identification and analysis of known, novel, or chemically modified neuropeptides may be obtained using mass spectrometric techniques. Because mass spectrometry techniques can be used to reflect the dynamic properties associated with neuropeptide processing in biological systems, they may be used in the future to monitor peptide profiles within organisms in response to environmental challenges such as disease and stress.

Details

Authors
External organisations
  • University of Gothenburg
Research areas and keywords

Keywords

  • Mass Spectrometry, Neurochemistry, Neuropeptides, Specimen Handling, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Journal Article, Research Support, Non-U.S. Gov't, Review
Original languageEnglish
Pages (from-to)781-9
JournalPeptides
Volume19
Issue number4
Publication statusPublished - 1998
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes