Matching protein structures with fuzzy alignments

Research output: Contribution to journalArticle

Abstract

Unraveling functional and ancestral relationships between proteins as well as structure-prediction procedures require powerful protein-alignment methods. A structure-alignment method is presented where the problem is mapped onto a cost function containing both fuzzy (Potts) assignment variables and atomic coordinates. The cost function is minimized by using an iterative scheme, where at each step mean field theory methods at finite "temperatures" are used for determining fuzzy assignment variables followed by exact translation and rotation of atomic coordinates weighted by their corresponding fuzzy assignment variables. The approach performs very well when compared with other methods, requires modest central processing unit consumption, and is robust with respect to choice of iteration parameters for a wide range of proteins.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biophysics

Keywords

  • algorithm, mean field annealing, fuzzy assignment, dynamical programming
Original languageEnglish
Pages (from-to)11936-11940
JournalProceedings of the National Academy of Sciences
Volume100
Issue number21
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes