Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study

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Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study. / Conway, Marie C; McSorley, Emeir M; Mulhern, Maria S; Spence, Toni; Weslowska, Maria; Strain, J J; van Wijngaarden, Edwin; Davidson, Phil W; Myers, Gary J; Wahlberg, Karin E; Shamlaye, Conrad F; Cobice, Diego F; Hyland, Barry W; Pineda, Daniela; Broberg, Karin; Yeates, Alison J.

In: British Journal of Nutrition, 02.02.2021.

Research output: Contribution to journalArticle

Harvard

Conway, MC, McSorley, EM, Mulhern, MS, Spence, T, Weslowska, M, Strain, JJ, van Wijngaarden, E, Davidson, PW, Myers, GJ, Wahlberg, KE, Shamlaye, CF, Cobice, DF, Hyland, BW, Pineda, D, Broberg, K & Yeates, AJ 2021, 'Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study', British Journal of Nutrition. https://doi.org/10.1017/S0007114521000441

APA

Conway, M. C., McSorley, E. M., Mulhern, M. S., Spence, T., Weslowska, M., Strain, J. J., van Wijngaarden, E., Davidson, P. W., Myers, G. J., Wahlberg, K. E., Shamlaye, C. F., Cobice, D. F., Hyland, B. W., Pineda, D., Broberg, K., & Yeates, A. J. (2021). Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study. British Journal of Nutrition. https://doi.org/10.1017/S0007114521000441

CBE

Conway MC, McSorley EM, Mulhern MS, Spence T, Weslowska M, Strain JJ, van Wijngaarden E, Davidson PW, Myers GJ, Wahlberg KE, Shamlaye CF, Cobice DF, Hyland BW, Pineda D, Broberg K, Yeates AJ. 2021. Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study. British Journal of Nutrition. https://doi.org/10.1017/S0007114521000441

MLA

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Author

Conway, Marie C ; McSorley, Emeir M ; Mulhern, Maria S ; Spence, Toni ; Weslowska, Maria ; Strain, J J ; van Wijngaarden, Edwin ; Davidson, Phil W ; Myers, Gary J ; Wahlberg, Karin E ; Shamlaye, Conrad F ; Cobice, Diego F ; Hyland, Barry W ; Pineda, Daniela ; Broberg, Karin ; Yeates, Alison J. / Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study. In: British Journal of Nutrition. 2021.

RIS

TY - JOUR

T1 - Maternal and child FADS genotype as determinants of cord blood long chain polyunsaturated fatty acid (LCPUFA) concentrations in the Seychelles Child Development Study

AU - Conway, Marie C

AU - McSorley, Emeir M

AU - Mulhern, Maria S

AU - Spence, Toni

AU - Weslowska, Maria

AU - Strain, J J

AU - van Wijngaarden, Edwin

AU - Davidson, Phil W

AU - Myers, Gary J

AU - Wahlberg, Karin E

AU - Shamlaye, Conrad F

AU - Cobice, Diego F

AU - Hyland, Barry W

AU - Pineda, Daniela

AU - Broberg, Karin

AU - Yeates, Alison J

PY - 2021/2/2

Y1 - 2021/2/2

N2 - Optimal maternal long chain polyunsaturated fatty acid (LCPUFA) status is essential for the developing foetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and α-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). There is limited research on the influence of FADS genotype on cord PUFA status. The current study investigated the influence of maternal and child genetic variation in FADS genotype on cord blood PUFA status in a high fish-eating cohort. Cord blood samples (n=1088) collected from the Seychelles Child Development Study (SCDS) Nutrition Cohort 2 (NC2) were analysed for total serum PUFA. Of those with cord PUFA data available, maternal (n=1062) and child (n=916), FADS1 (rs174537, rs174561), FADS2 (rs174575), and FADS1-FADS2 (rs3834458) were determined. Regression analysis determined that maternal minor allele homozygosity was associated with lower cord blood concentrations of docosahexaenoic acid (DHA) and the sum of EPA+DHA. Lower cord blood AA concentrations were observed in children who were minor allele homozygous for rs3834458 (β=0.075; p=0.037). Children who were minor allele carriers for rs174537, rs174561, rs174575 and rs3834458 had a lower cord blood AA:LA ratio (p<0.05 for all). Both maternal and child FADS genotype were associated with cord LCPUFA concentrations, and therefore, the influence of FADS genotype was observed despite the high intake of preformed dietary LCPUFA from fish in this population.

AB - Optimal maternal long chain polyunsaturated fatty acid (LCPUFA) status is essential for the developing foetus. The fatty acid desaturase (FADS) genes are involved in the endogenous synthesis of LCPUFA. The minor allele of various FADS single nucleotide polymorphisms (SNPs) have been associated with increased maternal concentrations of the precursors linoleic acid (LA) and α-linolenic acid (ALA), and lower concentrations of arachidonic acid (AA) and docosahexaenoic acid (DHA). There is limited research on the influence of FADS genotype on cord PUFA status. The current study investigated the influence of maternal and child genetic variation in FADS genotype on cord blood PUFA status in a high fish-eating cohort. Cord blood samples (n=1088) collected from the Seychelles Child Development Study (SCDS) Nutrition Cohort 2 (NC2) were analysed for total serum PUFA. Of those with cord PUFA data available, maternal (n=1062) and child (n=916), FADS1 (rs174537, rs174561), FADS2 (rs174575), and FADS1-FADS2 (rs3834458) were determined. Regression analysis determined that maternal minor allele homozygosity was associated with lower cord blood concentrations of docosahexaenoic acid (DHA) and the sum of EPA+DHA. Lower cord blood AA concentrations were observed in children who were minor allele homozygous for rs3834458 (β=0.075; p=0.037). Children who were minor allele carriers for rs174537, rs174561, rs174575 and rs3834458 had a lower cord blood AA:LA ratio (p<0.05 for all). Both maternal and child FADS genotype were associated with cord LCPUFA concentrations, and therefore, the influence of FADS genotype was observed despite the high intake of preformed dietary LCPUFA from fish in this population.

U2 - 10.1017/S0007114521000441

DO - 10.1017/S0007114521000441

M3 - Article

C2 - 33526157

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 1475-2662

ER -