Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study

Research output: Contribution to journalArticle

Standard

Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study. / TEDDY Study Group; Silvis, Katherine; Aronsson, Carin A.; Liu, Xiang; Uusitalo, Ulla; Yang, Jimin; Tamura, Roy; Lernmark, Åke; Rewers, Marian; Hagopian, William; She, Jin Xiong; Simell, Olli; Toppari, Jorma; Ziegler, Anette; Akolkar, Beena; Krischer, Jeffrey; Virtanen, Suvi M.; Norris, Jill M.

In: Pediatric Diabetes, 08.11.2018.

Research output: Contribution to journalArticle

Harvard

TEDDY Study Group, Silvis, K, Aronsson, CA, Liu, X, Uusitalo, U, Yang, J, Tamura, R, Lernmark, Å, Rewers, M, Hagopian, W, She, JX, Simell, O, Toppari, J, Ziegler, A, Akolkar, B, Krischer, J, Virtanen, SM & Norris, JM 2018, 'Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study', Pediatric Diabetes. https://doi.org/10.1111/pedi.12794

APA

CBE

TEDDY Study Group, Silvis K, Aronsson CA, Liu X, Uusitalo U, Yang J, Tamura R, Lernmark Å, Rewers M, Hagopian W, She JX, Simell O, Toppari J, Ziegler A, Akolkar B, Krischer J, Virtanen SM, Norris JM. 2018. Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study. Pediatric Diabetes. https://doi.org/10.1111/pedi.12794

MLA

Vancouver

Author

TEDDY Study Group ; Silvis, Katherine ; Aronsson, Carin A. ; Liu, Xiang ; Uusitalo, Ulla ; Yang, Jimin ; Tamura, Roy ; Lernmark, Åke ; Rewers, Marian ; Hagopian, William ; She, Jin Xiong ; Simell, Olli ; Toppari, Jorma ; Ziegler, Anette ; Akolkar, Beena ; Krischer, Jeffrey ; Virtanen, Suvi M. ; Norris, Jill M. / Maternal dietary supplement use and development of islet autoimmunity in the offspring : TEDDY study. In: Pediatric Diabetes. 2018.

RIS

TY - JOUR

T1 - Maternal dietary supplement use and development of islet autoimmunity in the offspring

T2 - Pediatric Diabetes

AU - TEDDY Study Group

AU - Silvis, Katherine

AU - Aronsson, Carin A.

AU - Liu, Xiang

AU - Uusitalo, Ulla

AU - Yang, Jimin

AU - Tamura, Roy

AU - Lernmark, Åke

AU - Rewers, Marian

AU - Hagopian, William

AU - She, Jin Xiong

AU - Simell, Olli

AU - Toppari, Jorma

AU - Ziegler, Anette

AU - Akolkar, Beena

AU - Krischer, Jeffrey

AU - Virtanen, Suvi M.

AU - Norris, Jill M.

PY - 2018/11/8

Y1 - 2018/11/8

N2 - Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen-DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.

AB - Objective: We investigated the association between maternal use of vitamin D and omega-3 fatty acids (n-3 FAs) supplements during pregnancy and risk of islet autoimmunity (IA) in the offspring. Methods: The Environmental Determinants of Diabetes in the Young (TEDDY) Study is prospectively following 8676 children with increased genetic risk for type 1 diabetes in Finland, Germany, Sweden, and the United States. Blood samples were collected every 3 months between 3 and 48 months of age then every 6 months thereafter to determine persistent IA. Duration, frequency, and supplement dose during pregnancy were recalled by mothers at 3 to 4 months postpartum. Cumulative intakes of supplemental vitamin D and n-3 FAs were analyzed as continuous or binary variables. We applied time-to-event analysis to study the association between maternal supplement use and IA, adjusting for country, human leukocyte antigen-DR-DQ genotype, family history of type 1 diabetes and sex. Secondary outcomes included insulin autoantibodies (IAA) or glutamic acid decarboxylase (GADA) as the first appearing autoantibody. Results: As of February 2018, there were 747 (9.0%) children with IA. Vitamin D supplement intake during pregnancy (any vs none) was not associated with risk for IA (hazard ratio [HR] 1.11; 95% confidence interval [CI] 0.94, 1.31); neither was cumulative vitamin D supplement intake. Supplemental n-3 FA intake was similarly not associated with IA risk (HR: 1.19, 95% CI 0.98, 1.45). Similar lack of association was observed for either IAA or GADA as the first appearing autoantibody. Conclusions: The TEDDY cohort showed no evidence of benefit regarding IA risk for vitamin D or n-3 FA supplementation during pregnancy.

KW - dietary supplements

KW - islet autoimmunity

KW - omega-3 fatty acids

KW - pregnancy

KW - vitamin D

U2 - 10.1111/pedi.12794

DO - 10.1111/pedi.12794

M3 - Article

JO - Pediatric Diabetes

JF - Pediatric Diabetes

SN - 1399-543X

ER -