Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.

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Bibtex

@article{86f3c591ced84cacb57a277860fa8549,
title = "Maternal enterovirus infection during pregnancy as a risk factor in offspring diagnosed with type 1 diabetes between 15 and 30 years of age.",
abstract = "Maternal enterovirus infections during pregnancy may increase the risk of offspring developing type 1 diabetes during childhood. The aim of this study was to investigate whether gestational enterovirus infections increase the offspring's risk of type 1 diabetes later in life. Serum samples from 30 mothers without diabetes whose offspring developed type 1 diabetes between 15 and 25 years of age were analyzed for enterovirus-specific immunoglobulin M (IgM) antibodies and enterovirus genome (RNA), and compared to a control group. Among the index mothers, 9/30 (30%) were enterovirus IgM-positive, and none was positive for enterovirus RNA. In the control group, 14/90 (16%) were enterovirus IgM-positive, and 4/90 (4%) were positive for enterovirus RNA (n.s.). Boys of enterovirus IgM-positive mothers had approximately 5 times greater risk of developing diabetes (OR 4.63; 95% CI 1.22-17.6), as compared to boys of IgM-negative mothers (P < .025). These results suggest that gestational enterovirus infections may be related to the risk of offspring developing type 1 diabetes in adolescence and young adulthood.",
author = "Maria Elfving and Johan Svensson and Sami Oikarinen and Bj{\"o}rn Jonsson and Per Olofsson and G{\"o}ran Sundkvist and Bengt Lindberg and {\AA}ke Lernmark and Heikki Hy{\"o}ty and Sten Ivarsson",
year = "2008",
doi = "10.1155/2008/271958",
language = "English",
volume = "2008",
journal = "Experimental Diabetes Research",
issn = "1687-5214",
publisher = "Hindawi Limited",

}