Mathematical Modeling of Biofilms: Theory, Numerics and Applications

Research output: ThesisDoctoral Thesis (monograph)

Abstract

A biofilm is a complex and diverse aggregation of microorganisms at surface comprised of among different things a protective adhesive matrix of extracellular polymeric substance. Biofilm research represents a broad range of sciences joining efforts within an interdisciplinary field of research. This thesis deals with the modeling of biofilms using the most fundamental laws of physics; the conservation laws of mass and momentum for fluids. Common to all parts of this work is an aim to develop robust and general mathematical models readily applicable for computational use.

Two new biofilm models for growth are derived in this thesis; one describing and combining an individual description of microbial particles with a continuum representation of the biofilm matrix, and one a model based solely on a continuum framework of partial differential equations. The latter is applied in a bottom-up approach as a mass balance model for a Moving Bed biofilm process. Finally, an attempt of capturing the conservation of momentum for both water and biomass is presented. This will allow for viscoelastic and other constitutive properties to influence biomass structure (through growth or fluid shear stresses) as well as erosion and sloughing detachment; under basic laws of physics. All models are applied and demonstrated in silico; for examples such as growth, deformation and detachment under fluid shear stress.

Details

Authors
  • Erik Alpkvist
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Mathematics

Keywords

  • mathematical modeling, Mathematics, conservation laws, biofilm, Matematik
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
Award date2006 Dec 8
Publisher
  • Centre for Mathematical Sciences, Lund University
Print ISBNs978-91-628-6512-2
Publication statusPublished - 2006
Publication categoryResearch

Bibliographic note

Defence details Date: 2006-12-08 Time: 10:15 Place: Ubåtshallen, U301, Malmö Högskola External reviewer(s) Name: Dockery, Jack D. Title: Professor Affiliation: Department of Mathematical Sciences, Montana State University, Bozeman ---