Measurements of the optical properties of tissue in conjunction with photodynamic therapy

Research output: Contribution to journalArticle

Abstract

A simple optical dosimeter was used to measure the light intensity in rat liver and muscle in vivo with fibers positioned at different depths to investigate whether the light penetration changed during photodynamic therapy (PDT). The results were then correlated with measurements of the three optical-interaction coefficients mu(s), mu(a), and g for wavelengths in the range 500-800 nm for PDT-treated and nontreated rat liver and muscle tissue in vitro. A distinct increase in the absorption coefficient was seen immediately after treatment, in agreement with the decreasing light intensity observed during the treatment, as measured with the optical dosimeter. The collimated transmittance was measured with a narrow-beam setup, and an optical integrating sphere was used to measure the diffuse reflectance and total transmittance of the samples. The corresponding optical properties were obtained by spline interpolation of Monte Carlo-simulated data. To ensure that the measured values were correct, we performed calibration measurements with suspensions of polystyrene microspheres and ink

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Atom and Molecular Physics and Optics

Keywords

  • PHOTODYNAMIC THERAPY, LIGHT PENETRATION, OPTICAL PROPERTIES, TISSUE OPTICS
Original languageEnglish
Pages (from-to)4609-4619
JournalApplied Optics
Volume34
Issue number21
Publication statusPublished - 1995
Publication categoryResearch
Peer-reviewedYes

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Related research output

Enejder, A. M. K., 1997, Department of Physics, Lund University. 279 p.

Research output: ThesisDoctoral Thesis (compilation)

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