Mechanosensation: A Catch Bond That Only Hooks One Way

Research output: Contribution to journalReview article

Abstract

Single-molecule force spectroscopy and modeling have revealed that the adhesion molecule vinculin and F-actin form a catch bond that is dependent on the direction of forces along the actin filament. This may underlie the mechanisms by which cells sense directional physical cues.

Details

Authors
External organisations
  • National Heart Lung and Blood Institute
  • Rockefeller University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)R1158-R1160
JournalCurrent Biology
Volume27
Issue number21
Publication statusPublished - 2017 Nov 6
Publication categoryResearch
Peer-reviewedNo
Externally publishedYes