Melatonin receptor 1B gene rs10830963 polymorphism, depressive symptoms and glycaemic traits

Research output: Contribution to journalArticle

Abstract

Background: The association between depression and type 2 diabetes is bidirectional. Underlying biological determinants remain elusive. We examined whether a common melatonin receptor 1B gene diabetes risk variant rs10830963 influenced the associations between depressive symptoms and glycaemic traits. Materials: The Prevalence, Prediction and Prevention of Diabetes-Botnia Study participants (n = 4,455) with no diabetes who underwent an oral glucose tolerance test were genotyped for rs10830963 and completed the Mental Health Inventory on depressive symptoms. Results: The rs10830963 did not influence significantly the associations between depressive symptoms and glycaemic traits. Yet, the addition of each copy of the minor G allele of the rs1080963 and higher depressive symptoms were both, independent of each other, associated significantly with higher glucose response (glucose area under the curve), higher insulin resistance (Insulin Sensitivity Index) and lower insulin secretion (Disposition Index). Depressive symptoms, but not rs1080963, were also significantly associated with higher fasting insulin, insulin area under the curve and insulin resistance (Homeostasis Model Assessment, Homeostasis Model Assessment-2); rs1080963, but not depressive symptoms, was significantly associated with higher fasting glucose and lower Corrected Insulin Response. Conclusions: Our study shows that the diabetes risk variant rs10830963 does not contribute to the known comorbidity between depression and type 2 diabetes.Key messages The association between depression and type 2 diabetes is bidirectional. We tested whether a common variant rs10830963 in the gene encoding Melatonin Receptor 1B influences the known association between depressive symptoms and glycaemic traits in a population-based sample from Western Finland. The MTNR1B genetic diabetes risk variant rs10830963 does not contribute to the known comorbidity between depression and type 2 diabetes. Depressive symptoms and rs10830963 are associated with a worse glycaemic profile independently of each other.

Details

Authors
  • Kadri Haljas
  • Jari Lahti
  • Tiinamaija Tuomi
  • Bo Isomaa
  • Johan G. Eriksson
  • Leif Groop
  • Katri Räikkönen
Organisations
External organisations
  • University of Helsinki
  • Helsinki University Central Hospital
  • Folkhälsan Research Center
  • Department of Social Services and Health Care, Jakobstad
  • Finnish National Institute for Health and Welfare
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
  • Endocrinology and Diabetes

Keywords

  • Depression, diabetes, glycaemic traits, insulin sensitivity and resistance, melatonin, MTNR1B, psychological aspects
Original languageEnglish
Pages (from-to)704-712
JournalAnnals of Medicine
Volume50
Issue number8
Early online date2018 Sep 12
Publication statusPublished - 2018
Publication categoryResearch
Peer-reviewedYes