Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Research output: Contribution to journalArticle

Abstract

We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n = ~ 38,000 for LTL and ~ 81,000 for ALS in the European population; n = ~ 23,000 for LTL and ~ 4,100 for ALS in the Asian population). We further evaluated mediation roles of lipids in the pathway from LTL to ALS. The odds ratio per standard deviation decrease of LTL on ALS was 1.10 (95% CI 0.93–1.31, p = 0.274) in the European population and 0.75 (95% CI 0.53–1.07, p = 0.116) in the Asian population. This null association was also detected between LTL and frontotemporal dementia in the European population. However, we found that an indirect effect of LTL on ALS might be mediated by low density lipoprotein (LDL) or total cholesterol (TC) in the European population. These results were robust against extensive sensitivity analyses. Overall, our MR study did not support the direct causal association between LTL and the ALS risk in neither population, but provided suggestive evidence for the mediation role of LDL or TC on the influence of LTL and ALS in the European population. © 2020, The Author(s).

Details

Authors
  • International FTD-Genomics Consortium (IFGC)
  • Yixin Gao
  • MARIA LANDQVIST WALDÖ
  • Karin Nilsson
  • Christer Nilsson
  • Ping Zeng
Organisations
External organisations
  • Xuzhou Medical University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
  • Neurosciences
Original languageEnglish
Article number12184
JournalScientific Reports
Volume10
Issue number1
Publication statusPublished - 2020
Publication categoryResearch
Peer-reviewedYes