Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals

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Bibtex

@article{d6d94626512d44fe9b9b64fe5ad8cc6a,
title = "Mesial temporal tau is related to worse cognitive performance and greater neocortical tau load in amyloid-β–negative cognitively normal individuals",
abstract = "We examined whether mesial temporal (Me) tau relates to cognitive performance in 47 amyloid-β (Aβ)-negative, cognitively normal older adults (>60 years old). Me-tau was measured using [18F]flortaucipir–positron emission tomography standardized uptake value ratio. The effect of continuous and categorical (stratified at standardized uptake value ratio = 1.2 [21% Me-positive]) Me-tau on cognition (mini-mental state examination, pre-Alzheimer's cognitive composite, a memory composite, and a nonmemory composite score) was examined using general linear models, and associations between Me-tau and [18F]flortaucipir signal in the neocortex were assessed using voxelwise regressions (continuous) and voxelwise contrasts (categorical). In addition, we assessed the effect of age and Aβ burden on Me-tau. Both continuous and categorical Me-tau was associated with worse cognitive performance across all tests and with higher lateral temporal and parietal [18F]flortaucipir signal. Furthermore, we observed a marginal association between Me-tau and age, whereas there was no association with Aβ burden. Our findings indicate that Me-tau in Aβ-negative cognitively normal individuals, which is likely age-related (i.e., primary age-related tauopathy), might not be as benign as commonly thought.",
keywords = "Mesial temporal lobe, PART, PET, Tau",
author = "Colin Groot and Vincent Dor{\'e} and Joanne Robertson and Burnham, {Samantha C.} and Greg Savage and Rik Ossenkoppele and Rowe, {Christopher C.} and Villemagne, {Victor L.}",
year = "2021",
doi = "10.1016/j.neurobiolaging.2020.09.017",
language = "English",
volume = "97",
pages = "41--48",
journal = "Neurobiology of Aging",
issn = "1558-1497",
publisher = "Elsevier",

}