Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

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title = "Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12",
abstract = "Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico {"}look-up{"} of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls. Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p = 7.12 x 10(-11)) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695). Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.",
author = "Kilarski, {Laura L.} and Sefanja Achterberg and Devan, {William J.} and Matthew Traylor and Rainer Malik and Arne Lindgren and Guillame Pare and Pankaj Sharma and Agniesczka Slowik and Vincent Thijs and Matthew Walters and Worrall, {Bradford B.} and Sale, {Michele M.} and Ale Algra and Kappelle, {L. Jaap} and Cisca Wijmenga and Bo Norrving and Sandling, {Johanna K.} and Lars Roennblom and An Goris and Andre Franke and Cathie Sudlow and Rothwell, {Peter M.} and Christopher Levi and Holliday, {Elizabeth G.} and Myriam Fornage and Bruce Psaty and Solveig Gretarsdottir and Unnar Thorsteinsdottir and Sudha Seshadri and Mitchell, {Braxton D.} and Steven Kittner and Robert Clarke and Hopewell, {Jemma C.} and Bis, {Joshua C.} and Boncoraglio, {Giorgio B.} and James Meschia and Ikram, {M. Arfan} and Bj{\"o}rn Hansen and Joan Montaner and Gudmar Thorleifsson and Kari Stefanson and Jonathan Rosand and {de Bakker}, {Paul I. W.} and Martin Farrall and Martin Dichgans and Markus, {Hugh S.} and Steve Bevan",
year = "2014",
doi = "10.1212/WNL.0000000000000707",
language = "English",
volume = "83",
pages = "678--685",
journal = "Neurology",
issn = "1526-632X",
publisher = "American Academy of Neurology",
number = "8",