Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

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Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. / Kilarski, Laura L.; Achterberg, Sefanja; Devan, William J.; Traylor, Matthew; Malik, Rainer; Lindgren, Arne; Pare, Guillame; Sharma, Pankaj; Slowik, Agniesczka; Thijs, Vincent; Walters, Matthew; Worrall, Bradford B.; Sale, Michele M.; Algra, Ale; Kappelle, L. Jaap; Wijmenga, Cisca; Norrving, Bo; Sandling, Johanna K.; Roennblom, Lars; Goris, An; Franke, Andre; Sudlow, Cathie; Rothwell, Peter M.; Levi, Christopher; Holliday, Elizabeth G.; Fornage, Myriam; Psaty, Bruce; Gretarsdottir, Solveig; Thorsteinsdottir, Unnar; Seshadri, Sudha; Mitchell, Braxton D.; Kittner, Steven; Clarke, Robert; Hopewell, Jemma C.; Bis, Joshua C.; Boncoraglio, Giorgio B.; Meschia, James; Ikram, M. Arfan; Hansen, Björn; Montaner, Joan; Thorleifsson, Gudmar; Stefanson, Kari; Rosand, Jonathan; de Bakker, Paul I. W.; Farrall, Martin; Dichgans, Martin; Markus, Hugh S.; Bevan, Steve.

In: Neurology, Vol. 83, No. 8, 2014, p. 678-685.

Research output: Contribution to journalArticle

Harvard

Kilarski, LL, Achterberg, S, Devan, WJ, Traylor, M, Malik, R, Lindgren, A, Pare, G, Sharma, P, Slowik, A, Thijs, V, Walters, M, Worrall, BB, Sale, MM, Algra, A, Kappelle, LJ, Wijmenga, C, Norrving, B, Sandling, JK, Roennblom, L, Goris, A, Franke, A, Sudlow, C, Rothwell, PM, Levi, C, Holliday, EG, Fornage, M, Psaty, B, Gretarsdottir, S, Thorsteinsdottir, U, Seshadri, S, Mitchell, BD, Kittner, S, Clarke, R, Hopewell, JC, Bis, JC, Boncoraglio, GB, Meschia, J, Ikram, MA, Hansen, B, Montaner, J, Thorleifsson, G, Stefanson, K, Rosand, J, de Bakker, PIW, Farrall, M, Dichgans, M, Markus, HS & Bevan, S 2014, 'Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12', Neurology, vol. 83, no. 8, pp. 678-685. https://doi.org/10.1212/WNL.0000000000000707

APA

Kilarski, L. L., Achterberg, S., Devan, W. J., Traylor, M., Malik, R., Lindgren, A., ... Bevan, S. (2014). Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology, 83(8), 678-685. https://doi.org/10.1212/WNL.0000000000000707

CBE

Kilarski LL, Achterberg S, Devan WJ, Traylor M, Malik R, Lindgren A, Pare G, Sharma P, Slowik A, Thijs V, Walters M, Worrall BB, Sale MM, Algra A, Kappelle LJ, Wijmenga C, Norrving B, Sandling JK, Roennblom L, Goris A, Franke A, Sudlow C, Rothwell PM, Levi C, Holliday EG, Fornage M, Psaty B, Gretarsdottir S, Thorsteinsdottir U, Seshadri S, Mitchell BD, Kittner S, Clarke R, Hopewell JC, Bis JC, Boncoraglio GB, Meschia J, Ikram MA, Hansen B, Montaner J, Thorleifsson G, Stefanson K, Rosand J, de Bakker PIW, Farrall M, Dichgans M, Markus HS, Bevan S. 2014. Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. Neurology. 83(8):678-685. https://doi.org/10.1212/WNL.0000000000000707

MLA

Vancouver

Author

Kilarski, Laura L. ; Achterberg, Sefanja ; Devan, William J. ; Traylor, Matthew ; Malik, Rainer ; Lindgren, Arne ; Pare, Guillame ; Sharma, Pankaj ; Slowik, Agniesczka ; Thijs, Vincent ; Walters, Matthew ; Worrall, Bradford B. ; Sale, Michele M. ; Algra, Ale ; Kappelle, L. Jaap ; Wijmenga, Cisca ; Norrving, Bo ; Sandling, Johanna K. ; Roennblom, Lars ; Goris, An ; Franke, Andre ; Sudlow, Cathie ; Rothwell, Peter M. ; Levi, Christopher ; Holliday, Elizabeth G. ; Fornage, Myriam ; Psaty, Bruce ; Gretarsdottir, Solveig ; Thorsteinsdottir, Unnar ; Seshadri, Sudha ; Mitchell, Braxton D. ; Kittner, Steven ; Clarke, Robert ; Hopewell, Jemma C. ; Bis, Joshua C. ; Boncoraglio, Giorgio B. ; Meschia, James ; Ikram, M. Arfan ; Hansen, Björn ; Montaner, Joan ; Thorleifsson, Gudmar ; Stefanson, Kari ; Rosand, Jonathan ; de Bakker, Paul I. W. ; Farrall, Martin ; Dichgans, Martin ; Markus, Hugh S. ; Bevan, Steve. / Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12. In: Neurology. 2014 ; Vol. 83, No. 8. pp. 678-685.

RIS

TY - JOUR

T1 - Meta-analysis in more than 17,900 cases of ischemic stroke reveals a novel association at 12q24.12

AU - Kilarski, Laura L.

AU - Achterberg, Sefanja

AU - Devan, William J.

AU - Traylor, Matthew

AU - Malik, Rainer

AU - Lindgren, Arne

AU - Pare, Guillame

AU - Sharma, Pankaj

AU - Slowik, Agniesczka

AU - Thijs, Vincent

AU - Walters, Matthew

AU - Worrall, Bradford B.

AU - Sale, Michele M.

AU - Algra, Ale

AU - Kappelle, L. Jaap

AU - Wijmenga, Cisca

AU - Norrving, Bo

AU - Sandling, Johanna K.

AU - Roennblom, Lars

AU - Goris, An

AU - Franke, Andre

AU - Sudlow, Cathie

AU - Rothwell, Peter M.

AU - Levi, Christopher

AU - Holliday, Elizabeth G.

AU - Fornage, Myriam

AU - Psaty, Bruce

AU - Gretarsdottir, Solveig

AU - Thorsteinsdottir, Unnar

AU - Seshadri, Sudha

AU - Mitchell, Braxton D.

AU - Kittner, Steven

AU - Clarke, Robert

AU - Hopewell, Jemma C.

AU - Bis, Joshua C.

AU - Boncoraglio, Giorgio B.

AU - Meschia, James

AU - Ikram, M. Arfan

AU - Hansen, Björn

AU - Montaner, Joan

AU - Thorleifsson, Gudmar

AU - Stefanson, Kari

AU - Rosand, Jonathan

AU - de Bakker, Paul I. W.

AU - Farrall, Martin

AU - Dichgans, Martin

AU - Markus, Hugh S.

AU - Bevan, Steve

PY - 2014

Y1 - 2014

N2 - Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico "look-up" of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls. Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p = 7.12 x 10(-11)) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695). Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.

AB - Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data from 3,548 cases and 5,972 controls recruited from the ischemic stroke WTCCC2 study, and with summary statistics from a further 8,480 cases and 56,032 controls in the METASTROKE consortium. A final in silico "look-up" of 2 single nucleotide polymorphisms in 2,522 cases and 1,899 controls was performed. Associations were also examined in 1,088 cases with intracerebral hemorrhage and 1,102 controls. Results: In an overall analysis of 17,970 cases of ischemic stroke and 70,764 controls, we identified a novel association on chromosome 12q24 (rs10744777, odds ratio [OR] 1.10 [1.07-1.13], p = 7.12 x 10(-11)) with ischemic stroke. The association was with all ischemic stroke rather than an individual stroke subtype, with similar effect sizes seen in different stroke subtypes. There was no association with intracerebral hemorrhage (OR 1.03 [0.90-1.17], p = 0.695). Conclusion: Our results show, for the first time, a genetic risk locus associated with ischemic stroke as a whole, rather than in a subtype-specific manner. This finding was not associated with intracerebral hemorrhage.

U2 - 10.1212/WNL.0000000000000707

DO - 10.1212/WNL.0000000000000707

M3 - Article

VL - 83

SP - 678

EP - 685

JO - Neurology

T2 - Neurology

JF - Neurology

SN - 1526-632X

IS - 8

ER -